9E8M
Covalent inhibitor VVD-442 bound to the RAS binding domain (RBD) of PI3Ka
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | polymer | 144 | 16799.8 | 2 | UniProt (P42336) Pfam (PF00794) | Homo sapiens (human) | PtdIns-3-kinase subunit alpha,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha,p110alpha,Phosphoinositide-3-kinase catalytic alpha polypeptide,Serine/threonine protein kinase PIK3CA |
| 2 | C, D (A, B) | 1-[(1P)-5-bromo-2'-chloro[1,1'-biphenyl]-2-sulfonyl]-4-fluoro-N-[(2S)-4-(methanesulfonyl)butan-2-yl]piperidine-4-carboxamide | non-polymer | 610.0 | 2 | Chemie (A1BF9) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 68 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 33599.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1219.9 | |
| All* | Total formula weight | 34819.5 |
