9E6G

Locally Refined Cryo-EM map of 2G12 IgG BCR receptor lacking Fab region view

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Immunoglobulin heavy constant gamma 1	polymer	214	24129.3	2	UniProt (P01857)	Homo sapiens (human)	Ig gamma-1 chain C region,Ig gamma-1 chain C region EU,Ig gamma-1 chain C region KOL,Ig gamma-1 chain C region NIE
2	C (C)	B-cell antigen receptor complex-associated protein alpha chain	polymer	93	10493.7	1	UniProt (P11912)	Homo sapiens (human)	Ig-alpha,MB-1 membrane glycoprotein,Membrane-bound immunoglobulin-associated protein,Surface IgM-associated protein
3	D (D)	B-cell antigen receptor complex-associated protein beta chain	polymer	100	11675.2	1	UniProt (P40259)	Homo sapiens (human)	B-cell-specific glycoprotein B29,Ig-beta,Immunoglobulin-associated B29 protein
4	E, G (E, F)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	2	In PDB GlyTouCan (G22768VO)
5	F (H)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
6	H, I, J, K, L (C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG) PubChem (24139)

Sequence modifications

A, B: 22 - 235 (UniProt: P01857)

PDB	External Database	Details
Ala 84	Ser 181	conflict
Ala 119	Glu 216	conflict
Ala 120	Lys 217	conflict
Glu 142	Asp 239	variant
Met 144	Leu 241	variant
Ala 220	Asn 317	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	70427.5
Branched	Number of molecules	3
	Total formula weight	2246.0
Non-Polymers*	Number of molecules	5
	Total formula weight	1106.0
All*	Total formula weight	73779.6

*Water molecules are not included.