9E4Z

GluA2-gamma2 complex bound glutamate and cyclothiazide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Isoform Flip of Glutamate receptor 2	polymer	811	90967.7	4	UniProt (P19491) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060)	Rattus norvegicus (Norway rat)	GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2
2	E, F, G, H (E, F, G, H)	Voltage-dependent calcium channel gamma-2 subunit	polymer	208	23008.5	4	UniProt (O88602) Pfam (PF00822)	Mus musculus (house mouse)	Neuronal voltage-gated calcium channel gamma-2 subunit,Stargazin,Transmembrane AMPAR regulatory protein gamma-2,TARP gamma-2
3	I, L, O, P (A, B, C, D)	GLUTAMIC ACID	non-polymer		147.1	4	Chemie (GLU) PubChem (611) PubChem (23327) PubChem (33032)
4	J, K, M, N (A, B)	CYCLOTHIAZIDE	non-polymer		389.9	4	Chemie (CYZ) PubChem (21550932) PubChem (177678892) PubChem (44582559) PubChem (92142359) PubChem (98047041) PubChem (101691639) PubChem (5388988) PubChem (52949708) PubChem (92143401) PubChem (92215537) PubChem (98047042) PubChem (101691640) PubChem (2910) PubChem (657321) PubChem (5288009) PubChem (6603794) PubChem (11972587) PubChem (131842006)

Sequence modifications

A, B, C, D: 10 - 820 (UniProt: P19491)

PDB	External Database	Details
Glu 241	Asn 256	conflict
Leu 382	Val 397	conflict
-	Leu 399	deletion
-	Thr 400	deletion
-	Glu 401	deletion
-	Leu 402	deletion
-	Pro 403	deletion
-	Ser 404	deletion
Glu 384	Gly 405	conflict
Asp 385	Asn 406	conflict
Gln 392	Asn 413	conflict

E, F, G, H: 1002 - 1207 (UniProt: O88602)

PDB	External Database	Details
Thr 1208	-	expression tag
Gly 1209	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	455904.7
Non-Polymers*	Number of molecules	8
	Total formula weight	2148.0
All*	Total formula weight	458052.7

*Water molecules are not included.