9E4Y
GluA2-gamma2 complex bound to memantine, glutamate, and cyclothiazide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Isoform Flip of Glutamate receptor 2 | polymer | 811 | 90967.7 | 4 | UniProt (P19491) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (Norway rat) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2 |
| 2 | E, F, G, H (E, F, G, H) | Voltage-dependent calcium channel gamma-2 subunit | polymer | 208 | 23008.5 | 4 | UniProt (O88602) Pfam (PF00822) | Mus musculus (house mouse) | Neuronal voltage-gated calcium channel gamma-2 subunit,Stargazin,Transmembrane AMPAR regulatory protein gamma-2,TARP gamma-2 |
| 3 | I (A) | Memantine | non-polymer | 179.3 | 1 | Chemie (377) PubChem (4054) PubChem (22948656) PubChem (1263681) PubChem (6604403) PubChem (98043031) PubChem (11263842) | |||
| 4 | J, M, O, Q (A, B, C, D) | GLUTAMIC ACID | non-polymer | 147.1 | 4 | Chemie (GLU) PubChem (611) PubChem (23327) PubChem (33032) | |||
| 5 | K, L, N, P (A, B, C) | CYCLOTHIAZIDE | non-polymer | 389.9 | 4 | Chemie (CYZ) PubChem (2910) PubChem (21550932) PubChem (177678892) PubChem (44582559) PubChem (657321) PubChem (52949708) PubChem (5288009) PubChem (6603794) PubChem (92143401) PubChem (92215537) PubChem (11972587) PubChem (98047042) PubChem (92142359) PubChem (98047041) PubChem (101691639) PubChem (5388988) PubChem (101691640) PubChem (131842006) |
Sequence modifications
A, B, C, D: 10 - 820 (UniProt: P19491)
E, F, G, H: 1002 - 1207 (UniProt: O88602)
| PDB | External Database | Details |
|---|---|---|
| Glu 241 | Asn 256 | conflict |
| Leu 382 | Val 397 | conflict |
| - | Leu 399 | deletion |
| - | Thr 400 | deletion |
| - | Glu 401 | deletion |
| - | Leu 402 | deletion |
| - | Pro 403 | deletion |
| - | Ser 404 | deletion |
| Glu 384 | Gly 405 | conflict |
| Asp 385 | Asn 406 | conflict |
| Gln 392 | Asn 413 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Thr 1208 | - | expression tag |
| Gly 1209 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 455904.7 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 2327.3 | |
| All* | Total formula weight | 458232.0 |
