9DZH
Human GC-A bound to ANP and REGN5308
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Atrial natriuretic peptide receptor 1 | polymer | 1031 | 115702.8 | 2 | UniProt (P16066) | Homo sapiens (human) | Atrial natriuretic peptide receptor type A,ANP-A,ANPR-A,NPR-A,Guanylate cyclase A,GC-A |
| 2 | C (C) | Atrial natriuretic peptide | polymer | 28 | 3087.5 | 1 | UniProt (P01160) | Homo sapiens (human) | ANP,Alpha-atrial natriuretic peptide,Alpha-hANP,Atrial natriuretic factor,ANF,CDD-ANF,CDD-ANP (99-126),Cardionatrin,Pro atrial natriuretic factor 99-126,proANF 99-126 |
| 3 | D (H) | REGN5308 - Heavy chain | polymer | 227 | 24468.4 | 1 | Mus musculus | ||
| 4 | E (L) | REGN5308 - Light chain | polymer | 213 | 23323.9 | 1 | Mus musculus | ||
| 5 | F, H, J (D, F, I) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 6 | G, I (E, G) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 7 | K, N (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 8 | L, M, O (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 9 | P (H) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A, B: 0 - 1029 (UniProt: P16066)
| PDB | External Database | Details |
|---|---|---|
| Ala -1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 282285.5 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 2446.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 734.5 | |
| All* | Total formula weight | 285466.3 |
