9DXT
Ligand-binding and transmembrane domains of kainate receptor GluK2 in complex with positive allosteric modulator BPAM-344 and channel blocker Kukoamine-A
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Glutamate receptor ionotropic, kainate 2 | polymer | 908 | 102510.0 | 4 | UniProt (P42260) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (Norway rat) | GluK2,Glutamate receptor 6,GluR-6,GluR6 |
| 2 | BA, E, M, Q (C, A, B) | 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide | non-polymer | 242.3 | 4 | Chemie (2J9) | |||
| 3 | AA, CA, F, KA, LA... (C, A, D, B) | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 8 | Chemie (POV) | |||
| 4 | DA, EA, FA, G, GA... (C, A, D, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 16 | Chemie (NAG) | |||
| 5 | HA, IA, JA, K, L... (C, D, A, B) | CHOLESTEROL | non-polymer | 386.7 | 8 | Chemie (CLR) | |||
| 6 | OA, PA, U, V (D, B) | 1-deoxy-alpha-D-mannopyranose | non-polymer | 164.2 | 4 | Chemie (AH2) | |||
| 7 | SA (D) | N,N'-[butane-1,4-diylbis(azanediylpropane-3,1-diyl)]bis[3-(3,4-dihydroxyphenyl)propanamide] | non-polymer | 530.7 | 1 | Chemie (A1BDT) |
Sequence modifications
A, B, C, D: 1 - 908 (UniProt: P42260)
| PDB | External Database | Details |
|---|---|---|
| Val 567 | Ile 567 | conflict |
| Cys 571 | Tyr 571 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 410039.9 | |
| Non-Polymers* | Number of molecules | 41 |
| Total formula weight | 14869.5 | |
| All* | Total formula weight | 424909.4 |
