9DXR

Ligand-binding and transmembrane domains of kainate receptor GluK2 in complex with positive allosteric modulator BPAM-344 and channel blocker Nephilatoxin-8

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Glutamate receptor ionotropic, kainate 2	polymer	908	102510.0	4	UniProt (P42260) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060)	Rattus norvegicus (Norway rat)	GluK2,Glutamate receptor 6,GluR-6,GluR6
2	E, F, H, I, J... (E, F, H, I, J...)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	6	In PDB GlyTouCan (G42666HT)
3	G, K (G, K)	beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	2	In PDB GlyTouCan (G31886NL)
4	M, T, W, Y (A, B, C)	4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide	non-polymer		242.3	4	Chemie (2J9)
5	AA, BA, CA, DA, EA... (C, D, A, B)	(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate	non-polymer		760.1	16	Chemie (POV)
6	U (A)	N~1~-{5-[(N-{4-[(3-aminopropyl)amino]butyl}-beta-alanyl)amino]pentyl}-N~2~-[(1H-indol-3-yl)acetyl]-D-aspartamide	non-polymer		572.7	1	Chemie (A1BDS)

Sequence modifications

A, B, C, D: 1 - 908 (UniProt: P42260)

PDB	External Database	Details
Val 567	Ile 567	engineered mutation
Cys 571	Tyr 571	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	410039.9
Branched	Number of molecules	8
	Total formula weight	4043.8
Non-Polymers*	Number of molecules	21
	Total formula weight	13703.0
All*	Total formula weight	427786.7

*Water molecules are not included.