9DXP

Cryo-EM structure of human OATP1C1 in complex with thyroid hormone T4

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Solute carrier organic anion transporter family member 1C1	polymer	746	82539.3	1	UniProt (Q9NYB5) Pfam (PF03137) Pfam (PF07648)	Homo sapiens (human)	Organic anion transporter 1C1,OATP1C1,Organic anion transporter F,OATP-F,Organic anion transporter polypeptide-related protein 5,OAT-RP-5,OATP-RP5,Organic anion-transporting polypeptide 14,OATP-14,Solute carrier family 21 member 14,Thyroxine transporter
2	B (A)	3,5,3',5'-TETRAIODO-L-THYRONINE	non-polymer		776.9	1	Chemie (T44)
3	C (A)	CHOLESTEROL HEMISUCCINATE	non-polymer		486.7	1	Chemie (Y01)
4	D (A)	water	water		18.0	2	Chemie (HOH)

Sequence modifications

A: 1 - 712 (UniProt: Q9NYB5)

PDB	External Database	Details
Ala 713	-	expression tag
Ala 714	-	expression tag
Ala 715	-	expression tag
Leu 716	-	expression tag
Glu 717	-	expression tag
Val 718	-	expression tag
Leu 719	-	expression tag
Phe 720	-	expression tag
Gln 721	-	expression tag
Gly 722	-	expression tag
Pro 723	-	expression tag
Gly 724	-	expression tag
Ala 725	-	expression tag
Ala 726	-	expression tag
Glu 727	-	expression tag
Asp 728	-	expression tag
Gln 729	-	expression tag
Val 730	-	expression tag
Asp 731	-	expression tag
Pro 732	-	expression tag
Arg 733	-	expression tag
Leu 734	-	expression tag
Ile 735	-	expression tag
Asp 736	-	expression tag
Gly 737	-	expression tag
Lys 738	-	expression tag
His 739	-	expression tag
His 740	-	expression tag
His 741	-	expression tag
His 742	-	expression tag
His 743	-	expression tag
His 744	-	expression tag
His 745	-	expression tag
His 746	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	82539.3
Non-Polymers*	Number of molecules	2
	Total formula weight	1263.6
All*	Total formula weight	83802.9

*Water molecules are not included.