9DX7

LRRC8A:D Conformation 1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (C, A, B, D)	Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562	polymer	911	105530.1	4	UniProt (Q80WG5) UniProt (P0ABE8) Pfam (PF12534) Pfam (PF07361) Pfam (PF13855)	Mus musculus (house mouse)	Leucine-rich repeat-containing protein 8A,Protein ebouriffe,ebo,Cytochrome b-562
2	E, F (E, F)	Volume-regulated anion channel subunit LRRC8D	polymer	868	99317.9	2	UniProt (Q8BGR2) Pfam (PF13855) Pfam (PF12534)	Mus musculus (house mouse)	Leucine-rich repeat-containing protein 5,Leucine-rich repeat-containing protein 8D
3	G, H, I, J, K... (C, A, B, D, E...)	1,2-dioleoyl-sn-glycero-3-phosphoethanolamine	non-polymer		744.0	18	Chemie (PEE)

Sequence modifications

C, A, B, D: 1 - 68 (UniProt: Q80WG5)
C, A, B, D: 68 - 72 (UniProt: P0ABE8)

PDB	External Database	Details
Trp 68	Met 29	conflict
Ile 68	Val 39	conflict
Ala 72	Ser 122	conflict
Ile 72	His 124	conflict
Gln 72	Lys 125	conflict
Leu 72	-	linker

C, A, B, D: 72 - 810 (UniProt: Q80WG5)

PDB	External Database	Details
Ser 811	-	expression tag
Asn 812	-	expression tag
Ser 813	-	expression tag
Leu 814	-	expression tag
Glu 815	-	expression tag
Val 816	-	expression tag
Leu 817	-	expression tag
Phe 818	-	expression tag
Gln 819	-	expression tag

E, F: 1 - 859 (UniProt: Q8BGR2)

PDB	External Database	Details
Ser 860	-	expression tag
Asn 861	-	expression tag
Ser 862	-	expression tag
Glu 863	-	expression tag
Asn 864	-	expression tag
Leu 865	-	expression tag
Tyr 866	-	expression tag
Phe 867	-	expression tag
Gln 868	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	620756.1
Non-Polymers*	Number of molecules	18
	Total formula weight	13392.6
All*	Total formula weight	634148.8

*Water molecules are not included.