9DW8
Dephosphorylated (E1371Q)CFTR in complex with PKA-C
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cystic fibrosis transmembrane conductance regulator | polymer | 1480 | 168334.5 | 1 | UniProt (P13569) Pfam (PF00664) Pfam (PF00005) Pfam (PF14396) | Homo sapiens (human) | CFTR,ATP-binding cassette sub-family C member 7,Channel conductance-controlling ATPase,cAMP-dependent chloride channel |
| 2 | B (G) | cAMP-dependent protein kinase catalytic subunit alpha | polymer | 351 | 40757.6 | 1 | UniProt (P00517) Pfam (PF00069) | Bos taurus (domestic cattle) | PKA C-alpha |
| 3 | C, D (A) | N-(2-phenylethyl)adenosine 5'-(tetrahydrogen triphosphate) | non-polymer | 611.3 | 2 | Chemie (B44) | |||
| 4 | E, F, G, H (A, G) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 5 | I (G) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) |
Sequence modifications
A: 1 - 1480 (UniProt: P13569)
| PDB | External Database | Details |
|---|---|---|
| Gln 1371 | Glu 1371 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 209092.1 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1826.1 | |
| All* | Total formula weight | 210918.2 |
