9DTT

Cryo-EM structure of DENV2 NS5 in complex with Stem Loop A (SLA)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	RNA-directed RNA polymerase NS5	polymer	920	105611.2	1	UniProt (P14340) Pfam (PF01728) Pfam (PF00972) Pfam (PF20483)	dengue virus type 2	Non-structural protein 5
2	B (B)	stem loop A	polymer	70	22560.4	1	GenBank (AF038403.1)	dengue virus type 2	SLA
3	C, D (A)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)

Sequence modifications

A: 1 - 900 (UniProt: P14340)

PDB	External Database	Details
Met -19	-	expression tag
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Gly 0	-	expression tag
Val 221	Leu 2712	conflict
Val 321	Gly 2812	conflict
Arg 891	Lys 3382	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	128171.6
Non-Polymers*	Number of molecules	2
	Total formula weight	130.8
All*	Total formula weight	128302.4

*Water molecules are not included.