9DQH
CryoEM structure of Gq-coupled MRGPRD with a new agonist EP-2825
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mas-related G-protein coupled receptor member D | polymer | 322 | 36171.5 | 1 | UniProt (Q8TDS7) Pfam (PF00001) | Homo sapiens (human) | Beta-alanine receptor,G-protein coupled receptor TGR7 |
| 2 | B (B) | Gs-mini-Gq chimera | polymer | 246 | 28084.8 | 1 | Pfam (PF00503) UniProt (by SIFTS) (A0A590UJY2) | Homo sapiens | |
| 3 | C (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 345 | 37728.2 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 4 | D (D) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 5 | E (E) | scFv16 | polymer | 257 | 27409.6 | 1 | Mus musculus | ||
| 6 | F (A) | 2-({1-[2-(4-chlorophenyl)-2-methylpropanoyl]piperidin-4-yl}amino)-5,6,7,8-tetrahydroquinazolin-4(3H)-one | non-polymer | 429.0 | 1 | Chemie (A1BE2) |
Sequence modifications
A: 2 - 321 (UniProt: Q8TDS7)
C: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Pro 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 137255.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 429.0 | |
| All* | Total formula weight | 137684.2 |
