9DQ4
Crystal structure of engineered Ipilimumab (mipi.4) Fab in complex with mouse CTLA-4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cytotoxic T-lymphocyte protein 4 | polymer | 125 | 13916.6 | 1 | UniProt (P09793) Pfam (PF07686) | Mus musculus (mouse) | Cytotoxic T-lymphocyte-associated antigen 4,CTLA-4 |
| 2 | B (H) | mipi.4 heavy chain | polymer | 229 | 24708.7 | 1 | Homo sapiens (human) | ||
| 3 | C (L) | mipi.4 light chain | polymer | 215 | 23608.2 | 1 | Homo sapiens (human) | ||
| 4 | D (B) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 1 | In PDB GlyTouCan (G32152BH) | |||
| 5 | E, F, G (A, H, L) | water | water | 18.0 | 395 | Chemie (HOH) |
Sequence modifications
A: -1 - 116 (UniProt: P09793)
| PDB | External Database | Details |
|---|---|---|
| Gly 117 | - | expression tag |
| His 118 | - | expression tag |
| His 119 | - | expression tag |
| His 120 | - | expression tag |
| His 121 | - | expression tag |
| His 122 | - | expression tag |
| His 123 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 62233.5 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 732.7 | |
| All* | Total formula weight | 62966.2 |
