9DOM
PVTX-405: A Potent, Highly Selective, and Orally Efficacious Molecular Glue Degrader of IKZF2 for Cancer Immunotherapy
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, C, E, G) | Protein cereblon | polymer | 111 | 12309.1 | 4 | UniProt (Q96SW2) Pfam (PF03226) | Homo sapiens (human) | |
| 2 | B, D, F, H (B, D, F, H) | Zinc finger protein Helios | polymer | 30 | 3300.8 | 4 | UniProt (Q9UKS7) Pfam (PF00096) | Homo sapiens (human) | Ikaros family zinc finger protein 2 |
| 3 | I, L, O, R (A, C, E, G) | (3S)-3-(1'-benzyl-6-oxo-6,8-dihydro-2H,7H-spiro[furo[2,3-e]isoindole-3,4'-piperidin]-7-yl)piperidine-2,6-dione | non-polymer | 445.5 | 4 | Chemie (A1A8N) | |||
| 4 | J, K, M, N, P... (A, B, C, D, E...) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 5 | AA, BA, U, V, W... (G, H, A, B, C...) | water | water | 18.0 | 277 | Chemie (HOH) |
Sequence modifications
A, C, E, G: 319 - 426 (UniProt: Q96SW2)
B, D, F, H: 136 - 164 (UniProt: Q9UKS7)
| PDB | External Database | Details |
|---|---|---|
| Gly 316 | - | expression tag |
| Pro 317 | - | expression tag |
| Ser 318 | - | expression tag |
| Ser 322 | Cys 322 | conflict |
| Ser 343 | Cys 343 | conflict |
| Ser 366 | Cys 366 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 135 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 62439.3 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2305.3 | |
| All* | Total formula weight | 64744.6 |
