9DM6
Crystal Structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with an ethylhydrazide inhibitor
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (B, A, C, D) | Hdac6 protein | polymer | 364 | 40285.5 | 4 | UniProt (A7YT55) Pfam (PF00850) UniProt (by SIFTS) (F8W4B7) | Danio rerio (zebrafish) | Histone Deacetylase 6 |
| 2 | AA, E, M, S (D, B, A, C) | N-[2-(benzylamino)-2-oxoethyl]-4-(dimethylamino)-N-{[4-(2-ethylhydrazine-1-carbonyl)phenyl]methyl}benzamide | non-polymer | 487.6 | 4 | Chemie (A1A6L) | |||
| 3 | BA, CA, DA, F, G... (D, B, A, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 13 | Chemie (EDO) | |||
| 4 | EA, J, P, X (D, B, A, C) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 5 | FA, GA, K, L, Q... (D, B, A, C) | POTASSIUM ION | non-polymer | 39.1 | 8 | Chemie (K) | |||
| 6 | HA, IA, JA, KA (B, A, C, D) | water | water | 18.0 | 1476 | Chemie (HOH) |
Sequence modifications
B, A, C, D: 440 - 798 (UniProt: A7YT55)
| PDB | External Database | Details |
|---|---|---|
| Ser 435 | - | expression tag |
| Asn 436 | - | expression tag |
| Ala 437 | - | expression tag |
| Gly 438 | - | expression tag |
| Gly 439 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 161141.9 | |
| Non-Polymers* | Number of molecules | 29 |
| Total formula weight | 3331.7 | |
| All* | Total formula weight | 164473.6 |
