9DLP

Cryo-EM structure of human TREX-2 complex bound to DDX39B(UAP56)

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Germinal-center associated nuclear protein	polymer	648	72607.6	1	UniProt (O60318) Pfam (PF03399)	Homo sapiens (human)	GANP,80 kDa MCM3-associated protein,MCM3 acetylating protein,MCM3AP,MCM3 acetyltransferase
2	B (B)	PCI domain-containing protein 2	polymer	399	46095.9	1	UniProt (Q5JVF3) Pfam (PF01399)	Homo sapiens (human)	CSN12-like protein
3	C (C)	26S proteasome complex subunit SEM1	polymer	70	8284.6	1	UniProt (P60896) Pfam (PF05160)	Homo sapiens (human)	26S proteasome complex subunit DSS1,Deleted in split hand/split foot protein 1,Split hand/foot deleted protein 1,Split hand/foot malformation type 1 protein
4	D (D)	Spliceosome RNA helicase DDX39B	polymer	433	49567.9	1	UniProt (Q13838) Pfam (PF00270) Pfam (PF00271)	Homo sapiens (human)	56 kDa U2AF65-associated protein,ATP-dependent RNA helicase p47,DEAD box protein UAP56,HLA-B-associated transcript 1 protein
5	E (D)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	1	Chemie (ADP)
6	F (D)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)

Sequence modifications

A: 358 - 1000 (UniProt: O60318)

PDB	External Database	Details
Gly 353	-	expression tag
Ala 354	-	expression tag
Met 355	-	expression tag
Gly 356	-	expression tag
Ser 357	-	expression tag

D: 1 - 428 (UniProt: Q13838)

PDB	External Database	Details
Gly -4	-	expression tag
Ala -3	-	expression tag
Met -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
A1amm 108	Glu 108	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	176556.0
Non-Polymers*	Number of molecules	2
	Total formula weight	451.5
All*	Total formula weight	177007.5

*Water molecules are not included.