9DKP

The structure of human vacuolar protein sorting 34 catalytic domain bound to RD-I-53

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	Phosphatidylinositol 3-kinase catalytic subunit type 3	polymer	594	68149.9	1	UniProt (Q8NEB9) Pfam (PF00613) Pfam (PF00454)	Homo sapiens (human)	PI3-kinase type 3,PI3K type 3,PtdIns-3-kinase type 3,Phosphatidylinositol 3-kinase p100 subunit,Phosphoinositide-3-kinase class 3,hVps34
2	B (B)	(8R)-3-(1,3-benzothiazol-2-yl)pyrazolo[1,5-a]pyrimidine	non-polymer		252.3	1	Chemie (A1A6F)
3	C (B)	2-ETHOXYETHANOL	non-polymer		90.1	1	Chemie (ETX)
4	D, E (B)	diethyl ether	non-polymer		74.1	2	Chemie (ETZ)
5	F (B)	DIMETHYL SULFOXIDE	non-polymer		78.1	1	Chemie (DMS)
6	G, H (B)	POTASSIUM ION	non-polymer		39.1	2	Chemie (K)
7	I, J, K, L, M... (B)	CHLORIDE ION	non-polymer		35.5	13	Chemie (CL)
8	V (B)	water	water		18.0	112	Chemie (HOH)

Sequence modifications

B: 290 - 871 (UniProt: Q8NEB9)

PDB	External Database	Details
Met 278	-	expression tag
Gly 279	-	expression tag
His 280	-	expression tag
His 281	-	expression tag
His 282	-	expression tag
His 283	-	expression tag
His 284	-	expression tag
His 285	-	expression tag
His 286	-	expression tag
His 287	-	expression tag
His 288	-	expression tag
His 289	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	68149.9
Non-Polymers*	Number of molecules	20
	Total formula weight	1107.9
All*	Total formula weight	69257.7

*Water molecules are not included.