9DIO
Crystal structure of H5 hemagglutinin Q226L mutant from the influenza virus A/Texas/37/2024 (H5N1) with LSTc
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G, I... (A, C, E, G, I...) | Hemagglutinin HA1 | polymer | 325 | 36520.4 | 9 | UniProt (A0A8E4ZAK5) Pfam (PF00509) | Influenza A virus | |
| 2 | B, D, F, H, J... (B, D, F, H, J...) | Hemagglutinin HA2 | polymer | 176 | 20257.3 | 9 | UniProt (A0A6B7HQ27) Pfam (PF00509) UniProt (by SIFTS) (A0A8K1XY81) | Influenza A virus | |
| 3 | DA, S, W (d, S, W) | N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-galactopyranose | branched | 836.7 | 3 | In PDB GlyTouCan (G03509EL) | |||
| 4 | T (T) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 5 | BA, CA, FA, U, V... (b, c, f, U, V...) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 7 | In PDB GlyTouCan (G15407YE) | |||
| 6 | Y (Y) | N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 674.6 | 1 | In PDB BIRD (PRD_900046) GlyTouCan (G73578JC) | |||
| 7 | AA (a) | N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose | branched | 998.9 | 1 | In PDB GlyTouCan (G28582XU) | |||
| 8 | EA (e) | N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-galactopyranose | branched | 836.7 | 1 | In PDB | |||
| 9 | GA, HA, IA, JA, KA... (A, B, C, E, G...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 16 | Chemie (NAG) | |||
| 10 | AB, BB, CB, DB, EB... (E, F, G, H, I...) | water | water | 18.0 | 265 | Chemie (HOH) |
Sequence modifications
A, C, E, G, I, K, M, O, Q: 11 - 324 (UniProt: A0A8E4ZAK5)
B, D, F, H, J, L, N, P, R: 1 - 174 (UniProt: A0A6B7HQ27)
| PDB | External Database | Details |
|---|---|---|
| Ala 7 | - | expression tag |
| Asp 8 | - | expression tag |
| Pro 9 | - | expression tag |
| Gly 10 | - | expression tag |
| Met 111 | Leu 120 | conflict |
| Gln 122 | Leu 131 | engineered mutation |
| Ile 199 | Thr 211 | conflict |
| Ala 214 | Val 226 | conflict |
| Leu 226 | Gln 238 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ser 175 | - | expression tag |
| Gly 176 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 18 |
| Total formula weight | 510999.7 | |
| Branched | Number of molecules | 14 |
| Total formula weight | 9550.7 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 3539.3 | |
| All* | Total formula weight | 524089.7 |
