9DI1
Cryo-EM structure of the USP1-UAF1-Ubiquitin complex inhibited by KSQ-4279
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | WD repeat-containing protein 48 | polymer | 677 | 76312.4 | 1 | UniProt (Q8TAF3) Pfam (PF00400) Pfam (PF11816) | Homo sapiens (human) | USP1-associated factor 1,WD repeat endosomal protein,p80 |
| 2 | B (B) | Ubiquitin carboxyl-terminal hydrolase 1 | polymer | 785 | 88321.2 | 1 | UniProt (O94782) Pfam (PF00443) | Homo sapiens (human) | Deubiquitinating enzyme 1,hUBP,Ubiquitin thioesterase 1,Ubiquitin-specific-processing protease 1 |
| 3 | C (C) | Ubiquitin | polymer | 75 | 8519.8 | 1 | UniProt (P0CG48) Pfam (PF00240) | Homo sapiens (human) | |
| 4 | D (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | E (B) | 6-(4-cyclopropyl-6-methoxy-pyrimidin-5-yl)-1-[[4-[1-propan-2-yl-4-(trifluoromethyl)imidazol-2-yl]phenyl]methyl]pyrazolo[3,4-d]pyrimidine | non-polymer | 534.5 | 1 | Chemie (A1IB8) | |||
| 6 | F (B) | 3-(methanesulfonyl)propan-1-amine | non-polymer | 137.2 | 1 | Chemie (A1A4Y) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 173153.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 737.1 | |
| All* | Total formula weight | 173890.6 |
