9DHW
Q23.MD39 in Complex with Fabs from antibodies CH01 iGL and 35O22
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, G (A, C, G) | Q23.MD39 Surface protein gp120 | polymer | 467 | 52753.8 | 3 | UniProt (O55774) Pfam (PF00516) | Human immunodeficiency virus 1 | |
| 2 | B, D, I (B, D, I) | Q23.MD39 Transmembrane protein gp41 | polymer | 153 | 17329.6 | 3 | UniProt (O55774) Pfam (PF00517) | Human immunodeficiency virus 1 | |
| 3 | E, H (E, H) | 35O22 Fab Heavy Chain | polymer | 243 | 26170.5 | 2 | Homo sapiens | ||
| 4 | F, J (F, L) | 35O22 Fab Light Chain | polymer | 216 | 23318.8 | 2 | Homo sapiens | ||
| 5 | K (M) | CH01 iGL Fab Light Chain | polymer | 108 | 11663.9 | 1 | Homo sapiens | ||
| 6 | L (N) | CH01 iGL Fab Heavy Chain | polymer | 133 | 14541.0 | 1 | Homo sapiens | ||
| 7 | M (J) | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G09724ZC) | |||
| 8 | AA, CA, DA, EA, IA... (a, c, d, e, i...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 16 | In PDB GlyTouCan (G42666HT) | |||
| 9 | O (O) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 1 | In PDB GlyTouCan (G46836GH) | |||
| 10 | HA, Q, S, U (h, Q, S, U) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 4 | In PDB GlyTouCan (G15407YE) | |||
| 11 | T (T) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 1 | In PDB GlyTouCan (G86851RC) | |||
| 12 | V (V) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 13 | GA, W (g, W) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 2 | In PDB GlyTouCan (G42227JK) | |||
| 14 | BA (b) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1397.2 | 1 | In PDB GlyTouCan (G80966KZ) | |||
| 15 | FA (f) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 1 | In PDB GlyTouCan (G32152BH) | |||
| 16 | AB, BB, CB, DB, EB... (C, D, G, A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 22 | Chemie (NAG) |
Sequence modifications
A, C, G: 32 - 507 (UniProt: O55774)
B, D, I: 512 - 664 (UniProt: O55774)
| PDB | External Database | Details |
|---|---|---|
| Glu 106 | Thr 105 | engineered mutation |
| Ile 271 | Thr 263 | engineered mutation |
| Val 304 | Arg 296 | engineered mutation |
| Tyr 319 | Ala 309 | engineered mutation |
| Gln 363 | Asn 353 | engineered mutation |
| Ser 473 | Gly 463 | engineered mutation |
| Cys 501 | Ala 491 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 519 | Phe 509 | engineered mutation |
| Ala 533 | Thr 523 | engineered mutation |
| Pro 559 | Ile 549 | engineered mutation |
| Pro 561 | Ala 551 | engineered mutation |
| Asp 568 | Leu 558 | engineered mutation |
| His 570 | Val 560 | engineered mutation |
| His 585 | Arg 575 | engineered mutation |
| Cys 605 | Thr 595 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 335433.7 | |
| Branched | Number of molecules | 28 |
| Total formula weight | 16674.4 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 4866.6 | |
| All* | Total formula weight | 356974.6 |
