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9DH3

Cryo-EM structure of NLRP3 complex with Compound C

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D
(A, B, C, D)
Maltose/maltodextrin-binding periplasmic protein,NACHT, LRR and PYD domains-containing protein 3 chimerapolymer1267142837.84UniProt (P0AEX9)
UniProt (Q96P20)
Pfam (PF01547)
Pfam (PF14484)
Pfam (PF05729)
Pfam (PF17779)
Pfam (PF17776)
Pfam (PF13516)
Homo sapiens (human)MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP,Angiotensin/vasopressin receptor AII/AVP-like,Caterpiller protein 1.1,CLR1.1,Cold-induced autoinflammatory syndrome 1 protein,Cryopyrin,PYRIN-containing APAF1-like protein 1
2E, H, K, N
(A, B, C, D)
ADENOSINE-5'-DIPHOSPHATEnon-polymer427.24Chemie (ADP)
3F, I, L, O
(A, B, C, D)
2-[(4S)-5-ethyl-8-oxothieno[2',3':4,5]pyrrolo[1,2-d][1,2,4]triazin-7(8H)-yl]-N-(pyrimidin-4-yl)acetamidenon-polymer354.44Chemie (A1A4L)
4G, J, M, P
(A, B, C, D)
3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATEnon-polymer614.94Chemie (CPS)
Sequence modifications
A, B, C, D: -230 - 135 (UniProt: P0AEX9)
PDBExternal DatabaseDetails
Val 81Ala 338conflict
A, B, C, D: 136 - 1036 (UniProt: Q96P20)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight571351.1
Non-Polymers*Number of molecules12
Total formula weight5585.9
All*Total formula weight576936.9
*Water molecules are not included.

238895

PDB entries from 2025-07-16

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