Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Epidermal growth factor receptor | polymer | 333 | 37864.7 | 1 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | B (A) | (2P)-3-(3-chloro-2-methoxyanilino)-2-[3-({(2R)-1-[(2E)-4-(dimethylamino)but-2-enoyl]-2-methylpyrrolidin-2-yl}ethynyl)pyridin-4-yl]-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one | non-polymer | 587.1 | 1 | Chemie (A1A4E) | |||
| 3 | C, D, E, F (A) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 4 | G, H, I, J, K... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 9 | Chemie (EDO) | |||
| 5 | P, Q, R, S, T... (A) | GLYCEROL | non-polymer | 92.1 | 10 | Chemie (GOL) | |||
| 6 | Z (A) | water | water | 18.0 | 218 | Chemie (HOH) |
Sequence modifications
A: 696 - 1025 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 693 | - | expression tag |
| Gly 694 | - | expression tag |
| Ser 695 | - | expression tag |
| Ser 768 | - | insertion |
| Val 769 | - | insertion |
| Asp 770 | - | insertion |
| Arg 951 | Val 948 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37864.7 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 2208.5 | |
| All* | Total formula weight | 40073.1 |
