9DEQ

Cryo-EM structures of full-length integrin alphaIIbbeta3 in native lipids complexed with modified tirofiban

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Integrin alpha-IIb	polymer	1008	110106.4	1	UniProt (P08514) Pfam (PF01839) Pfam (PF08441) Pfam (PF20805) Pfam (PF20806) Pfam (PF00357)	Homo sapiens (human)	GPalpha IIb,GPIIb,Platelet membrane glycoprotein IIb
2	B (B)	Integrin beta-3	polymer	762	84478.5	1	UniProt (P05106) Pfam (PF07974) Pfam (PF07965) Pfam (PF08725) Pfam (PF17205) Pfam (PF00362) Pfam (PF18372)	Homo sapiens (human)	Platelet membrane glycoprotein IIIa,GPIIIa
3	C, E, H (C, E, H)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	3	In PDB GlyTouCan (G15407YE)
4	D, G (D, G)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
5	F (F)	beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	1	In PDB GlyTouCan (G89225LT)
6	I, J, K, L, Q... (A, B)	CALCIUM ION	non-polymer		40.1	7	Chemie (CA)
7	M, N, O, P, R (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG)
8	S (B)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
9	V (B)	N-(1,3-benzoxazole-2-carbonyl)-O-[4-(piperidin-4-yl)butyl]-L-tyrosine	non-polymer		465.5	1	Chemie (A1A5G)
10	W, X (B)	CHOLESTEROL	non-polymer		386.7	2	Chemie (CLR)
11	Y (B)	water	water		18.0	5	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	194584.9
Branched	Number of molecules	6
	Total formula weight	3519.3
Non-Polymers*	Number of molecules	16
	Total formula weight	2649.7
All*	Total formula weight	200753.9

*Water molecules are not included.