9DC6
Structure of J-PKAc chimera in complex with Aplithianine e1
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | cAMP-dependent protein kinase catalytic subunit alpha | polymer | 405 | 47512.0 | 2 | UniProt (P17612) Pfam (PF00069) | Homo sapiens (human) | PKA C-alpha |
| 2 | C, D (I, J) | cAMP-dependent protein kinase inhibitor alpha | polymer | 20 | 2226.4 | 2 | UniProt (P61925) | Homo sapiens | PKI-alpha,cAMP-dependent protein kinase inhibitor,muscle/brain isoform |
| 3 | E, F (A, B) | N-(2-aminoethyl)-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3,4-dihydro-2H-1,4-thiazine-6-carboxamide | non-polymer | 304.4 | 2 | Chemie (A1A3I) |
Sequence modifications
A, B: 70 - 405 (UniProt: P17612)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Lys 2 | - | expression tag |
| Asp 3 | - | expression tag |
| Tyr 4 | - | expression tag |
| Tyr 5 | - | expression tag |
| Gln 6 | - | expression tag |
| Thr 7 | - | expression tag |
| Leu 8 | - | expression tag |
| Gly 9 | - | expression tag |
| Leu 10 | - | expression tag |
| Ala 11 | - | expression tag |
| Arg 12 | - | expression tag |
| Gly 13 | - | expression tag |
| Ala 14 | - | expression tag |
| Ser 15 | - | expression tag |
| Asp 16 | - | expression tag |
| Glu 17 | - | expression tag |
| Glu 18 | - | expression tag |
| Ile 19 | - | expression tag |
| Lys 20 | - | expression tag |
| Arg 21 | - | expression tag |
| Ala 22 | - | expression tag |
| Tyr 23 | - | expression tag |
| Arg 24 | - | expression tag |
| Arg 25 | - | expression tag |
| Gln 26 | - | expression tag |
| Ala 27 | - | expression tag |
| Leu 28 | - | expression tag |
| Arg 29 | - | expression tag |
| Tyr 30 | - | expression tag |
| His 31 | - | expression tag |
| Pro 32 | - | expression tag |
| Asp 33 | - | expression tag |
| Lys 34 | - | expression tag |
| Asn 35 | - | expression tag |
| Lys 36 | - | expression tag |
| Glu 37 | - | expression tag |
| Pro 38 | - | expression tag |
| Gly 39 | - | expression tag |
| Ala 40 | - | expression tag |
| Glu 41 | - | expression tag |
| Glu 42 | - | expression tag |
| Lys 43 | - | expression tag |
| Phe 44 | - | expression tag |
| Lys 45 | - | expression tag |
| Glu 46 | - | expression tag |
| Ile 47 | - | expression tag |
| Ala 48 | - | expression tag |
| Glu 49 | - | expression tag |
| Ala 50 | - | expression tag |
| Tyr 51 | - | expression tag |
| Asp 52 | - | expression tag |
| Val 53 | - | expression tag |
| Leu 54 | - | expression tag |
| Ser 55 | - | expression tag |
| Asp 56 | - | expression tag |
| Pro 57 | - | expression tag |
| Arg 58 | - | expression tag |
| Lys 59 | - | expression tag |
| Arg 60 | - | expression tag |
| Glu 61 | - | expression tag |
| Ile 62 | - | expression tag |
| Phe 63 | - | expression tag |
| Asp 64 | - | expression tag |
| Arg 65 | - | expression tag |
| Tyr 66 | - | expression tag |
| Gly 67 | - | expression tag |
| Glu 68 | - | expression tag |
| Glu 69 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 99476.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 608.7 | |
| All* | Total formula weight | 100085.5 |
