9D9R

X-ray structure of ALX4 homeodomain dimer bound to DNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Homeobox protein aristaless-like 4	polymer	79	9690.0	2	UniProt (Q9H161) Pfam (PF00046)	Homo sapiens (human)
2	C (C)	DNA (5'-D(*CP*GP*CP*TP*AP*AP*TP*TP*CP*AP*AP*TP*TP*AP*AP*CP*G)-3')	polymer	17	5170.4	1		Homo sapiens
3	D (D)	DNA (5'-D(*CP*GP*TP*TP*AP*AP*TP*TP*GP*AP*AP*TP*TP*AP*GP*CP*G)-3')	polymer	17	5241.4	1		Homo sapiens
4	E, F (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
5	G, H (A, C)	water	water		18.0	2	Chemie (HOH)

Sequence modifications

A, B: 209 - 274 (UniProt: Q9H161)

PDB	External Database	Details
Gly 204	-	expression tag
Pro 205	-	expression tag
Ala 206	-	expression tag
Ala 207	-	expression tag
Ala 208	-	expression tag
Trp 275	-	expression tag
Ser 276	-	expression tag
His 277	-	expression tag
Pro 278	-	expression tag
Gln 279	-	expression tag
Phe 280	-	expression tag
Glu 281	-	expression tag
Lys 282	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	29791.8
Non-Polymers*	Number of molecules	2
	Total formula weight	124.1
All*	Total formula weight	29915.9

*Water molecules are not included.