9D8Z

Crystal structure of the ACVR1 (ALK2) Kinase Domain in complex with inhibitor CDD-2282

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Activin receptor type-1	polymer	332	37713.2	2	UniProt (Q04771) Pfam (PF08515) Pfam (PF00069)	Homo sapiens (human)	Activin receptor type I,ACTR-I,Activin receptor-like kinase 2,ALK-2,Serine/threonine-protein kinase receptor R1,SKR1,TGF-B superfamily receptor type I,TSR-I
2	C, H (A, B)	1-[(1r,3r)-3-(methylcarbamoyl)cyclobutyl]-N-[(1-methylpiperidin-4-yl)methyl]-2-(3,4,5-trimethoxyphenyl)-1H-1,3-benzimidazole-6-carboxamide	non-polymer		549.7	2	Chemie (A1A3D)
3	D, E, F, G, I... (A, B)	PHOSPHATE ION	non-polymer		95.0	10	Chemie (PO4)
4	O, P (A, B)	water	water		18.0	256	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	75426.3
Non-Polymers*	Number of molecules	12
	Total formula weight	2049.0
All*	Total formula weight	77475.4

*Water molecules are not included.