9D8F
Crystal structure of the ACVR1 (ALK2) Kinase Domain in complex with inhibitor CDD-2281
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Activin receptor type-1 | polymer | 317 | 36223.6 | 2 | UniProt (Q04771) Pfam (PF08515) Pfam (PF00069) | Homo sapiens (human) | Activin receptor type I,ACTR-I,Activin receptor-like kinase 2,ALK-2,Serine/threonine-protein kinase receptor R1,SKR1,TGF-B superfamily receptor type I,TSR-I |
| 2 | C, D, E, F, G... (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 10 | Chemie (PO4) | |||
| 3 | I, O (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 4 | J, P (A, B) | N-[3-(dimethylamino)propyl]-1-[(1r,3r)-3-(methylcarbamoyl)cyclobutyl]-2-(3,4,5-trimethoxyphenyl)-1H-1,3-benzimidazole-6-carboxamide | non-polymer | 523.6 | 2 | Chemie (A1A3C) | |||
| 5 | Q, R (A, B) | water | water | 18.0 | 257 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 72447.2 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 2181.1 | |
| All* | Total formula weight | 74628.3 |
