9D8E
Crystal structure of the ACVR1 (ALK2) Kinase Domain in complex with inhibitor CDD-2789
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Activin receptor type-1 | polymer | 330 | 37398.7 | 2 | UniProt (Q04771) Pfam (PF08515) Pfam (PF00069) | Homo sapiens (human) | Activin receptor type I,ACTR-I,Activin receptor-like kinase 2,ALK-2,Serine/threonine-protein kinase receptor R1,SKR1,TGF-B superfamily receptor type I,TSR-I |
| 2 | C, D, L (A, B) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 3 | E, K (A, B) | 1-cyclobutyl-N-[3-(dimethylamino)propyl]-2-(3,4,5-trimethoxyphenyl)-1H-1,3-benzimidazole-6-carboxamide | non-polymer | 466.6 | 2 | Chemie (A1A29) | |||
| 4 | F, G, H, I, J... (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 9 | Chemie (PO4) | |||
| 5 | Q, R (A, B) | water | water | 18.0 | 296 | Chemie (HOH) |
Sequence modifications
A, B: 172 - 499 (UniProt: Q04771)
| PDB | External Database | Details |
|---|---|---|
| Ser 170 | - | expression tag |
| Met 171 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 74797.5 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 2064.2 | |
| All* | Total formula weight | 76861.7 |
