9D7O
Cryo-EM structure of BG505 DS-SOSIP.664 with 1 CH103 Fab bound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E (A, C, E) | Surface protein gp120 | polymer | 496 | 55359.9 | 3 | UniProt (Q2N0S5) Pfam (PF00516) UniProt (by SIFTS) (Q2N0S6) | Human immunodeficiency virus 1 | |
| 2 | B, D, F (B, D, F) | Transmembrane protein gp41 | polymer | 162 | 18345.0 | 3 | UniProt (Q2N0S5) Pfam (PF00517) UniProt (by SIFTS) (D0PUM0) | Human immunodeficiency virus 1 | |
| 3 | G (G) | CH103 Fab light chain | polymer | 278 | 29953.2 | 1 | Homo sapiens (human) | ||
| 4 | H (H) | CH103 Fab heavy chain | polymer | 245 | 25886.2 | 1 | Homo sapiens (human) | ||
| 5 | AA, BA, DA, EA, FA... (a, b, d, e, f...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 27 | In PDB GlyTouCan (G42666HT) | |||
| 6 | CA, IA, NA, O, OA... (c, i, n, O, o...) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 6 | In PDB GlyTouCan (G15407YE) | |||
| 7 | AB, BB, CB, DB, EB... (C, D, E, F, A...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 23 | Chemie (NAG) |
Sequence modifications
A, C, E: 8 - 504 (UniProt: Q2N0S5)
B, D, F: 503 - 664 (UniProt: Q2N0S5)
| PDB | External Database | Details |
|---|---|---|
| Met 7 | - | initiating methionine |
| Pro 8 | Asn 9 | conflict |
| Met 9 | Cys 10 | conflict |
| Gly 10 | Gln 11 | conflict |
| Ser 11 | His 12 | conflict |
| Gln 13 | Phe 14 | conflict |
| Pro 14 | Arg 15 | conflict |
| Leu 15 | Trp 16 | conflict |
| Ala 16 | Gly 17 | conflict |
| Leu 18 | - | insertion |
| Tyr 19 | Met 19 | conflict |
| Leu 20 | Ile 20 | conflict |
| Leu 24 | - | insertion |
| Val 25 | Ile 24 | conflict |
| Ala 26 | Ile 25 | conflict |
| Ser 27 | Ile 26 | conflict |
| Val 28 | Cys 27 | conflict |
| Leu 29 | Ser 28 | conflict |
| Cys 201 | Ile 200 | conflict |
| Asn 332 | Thr 330 | conflict |
| Cys 433 | Ala 430 | conflict |
| Cys 501 | Ala 498 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Arg 506 | - | insertion |
| Arg 507 | - | insertion |
| Arg 509 | Glu 506 | engineered mutation |
| Arg 510 | Lys 507 | engineered mutation |
| Pro 559 | Ile 556 | conflict |
| Cys 605 | Thr 602 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 276954.0 | |
| Branched | Number of molecules | 33 |
| Total formula weight | 14978.1 | |
| Non-Polymers* | Number of molecules | 23 |
| Total formula weight | 5087.8 | |
| All* | Total formula weight | 297019.9 |
