9D71
Crystal structure of Human Prostaglandin reductase 1 (PTGR1) in complex with methotrexate (P1 form)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Prostaglandin reductase 1 | polymer | 331 | 35968.7 | 4 | UniProt (Q14914) Pfam (PF16884) Pfam (PF00107) | Homo sapiens (human) | PRG-1,15-oxoprostaglandin 13-reductase,Dithiolethione-inducible gene 1 protein,D3T-inducible gene 1 protein,DIG-1,Leukotriene B4 12-hydroxydehydrogenase,NAD(P)H-dependent alkenal/one oxidoreductase |
| 2 | E, F, G (A, B, C) | METHOTREXATE | non-polymer | 454.4 | 3 | Chemie (MTX) | |||
| 3 | H, I, J, K (A, B, C, D) | water | water | 18.0 | 357 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 4 - 329 (UniProt: Q14914)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Pro 0 | - | expression tag |
| Gly 1 | - | expression tag |
| Ser 2 | - | expression tag |
| Met 3 | - | expression tag |
| Ser 27 | Ala 27 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 143874.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1363.3 | |
| All* | Total formula weight | 145238.3 |
