9D6P
Human p38alpha MAP Kinase in complex with (Naphthalen-1-yl)pyridazine derivative GDK767-7
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mitogen-activated protein kinase 14 | polymer | 346 | 39661.4 | 1 | UniProt (Q16539) Pfam (PF00069) | Homo sapiens (human) | MAP kinase 14,MAPK 14,Cytokine suppressive anti-inflammatory drug-binding protein,CSAID-binding protein,CSBP,MAP kinase MXI2,MAX-interacting protein 2,Mitogen-activated protein kinase p38 alpha,MAP kinase p38 alpha,Stress-activated protein kinase 2a,SAPK2a |
| 2 | B (A) | N',N'-dimethyl-N-(6-naphthalen-1-yl-5-pyridin-4-yl-pyridazin-3-yl)ethane-1,2-diamine | non-polymer | 369.5 | 1 | Chemie (A1IKD) | |||
| 3 | C, D (A) | 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE | non-polymer | 239.2 | 2 | Chemie (GG5) | |||
| 4 | E (A) | water | water | 18.0 | 23 | Chemie (HOH) |
Sequence modifications
A: 5 - 353 (UniProt: Q16539)
| PDB | External Database | Details |
|---|---|---|
| - | Gly 170 | deletion |
| - | Leu 171 | deletion |
| Ala 171 | Arg 173 | conflict |
| - | Thr 180 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39661.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 848.0 | |
| All* | Total formula weight | 40509.4 |
