9D1X
Crystal structure of FGFR3 bound to indazole inhibitor
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Fibroblast growth factor receptor 3 | polymer | 297 | 33742.0 | 1 | UniProt (P22607) | Homo sapiens (human) | FGFR-3 |
| 2 | B (A) | (3P)-N-(2,6-dimethylphenyl)-6-methoxy-3-(1-methyl-1H-pyrazol-4-yl)-1H-indazole-5-carboxamide | non-polymer | 375.4 | 1 | Chemie (A1A6M) | |||
| 3 | C (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | D (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | E (A) | water | water | 18.0 | 209 | Chemie (HOH) |
Sequence modifications
A: 455 - 756 (UniProt: P22607)
| PDB | External Database | Details |
|---|---|---|
| Met 454 | - | initiating methionine |
| - | Pro 572 | deletion |
| - | Pro 573 | deletion |
| - | Gly 574 | deletion |
| - | Leu 575 | deletion |
| - | Asp 576 | deletion |
| - | Tyr 577 | deletion |
| - | Ser 578 | deletion |
| - | Phe 579 | deletion |
| - | Asp 580 | deletion |
| - | Thr 581 | deletion |
| - | Cys 582 | deletion |
| - | Lys 583 | deletion |
| Ser 572 | Pro 584 | engineered mutation |
| Gly 573 | Pro 585 | engineered mutation |
| His 757 | - | expression tag |
| His 758 | - | expression tag |
| His 759 | - | expression tag |
| His 760 | - | expression tag |
| His 761 | - | expression tag |
| His 762 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33742.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 435.2 | |
| All* | Total formula weight | 34177.2 |
