9D0W
Cryo-EM structure of CDK2/CyclinE1 in complex with CRBN/DDB1 and Cpd 4
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA damage-binding protein 1 | polymer | 1148 | 128139.6 | 1 | UniProt (Q16531) Pfam (PF10433) Pfam (PF03178) | Homo sapiens (human) | DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe |
| 2 | B (B) | Protein cereblon | polymer | 405 | 46465.4 | 1 | UniProt (Q96SW2) Pfam (PF02190) Pfam (PF03226) | Homo sapiens (human) | |
| 3 | C (C) | Cyclin-dependent kinase 2 | polymer | 298 | 34056.5 | 1 | UniProt (P24941) Pfam (PF00069) | Homo sapiens (human) | Cell division protein kinase 2,p33 protein kinase |
| 4 | D (D) | G1/S-specific cyclin-E1 | polymer | 286 | 33140.6 | 1 | UniProt (P24864) Pfam (PF00134) Pfam (PF02984) | Homo sapiens (human) | |
| 5 | E (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 6 | F (B) | (3R)-3-(5-{4-[(2-{4-[(8-cyclopentyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino]-3-methylbenzene-1-sulfonyl}-7-azaspiro[3.5]nonan-7-yl)methyl]piperidin-1-yl}-4-fluoro-3-methyl-2-oxo-2,3-dihydro-1H-1,3-benzimidazol-1-yl)piperidine-2,6-dione | non-polymer | 880.0 | 1 | Chemie (A1A1I) |
Sequence modifications
A: 1 - 1140 (UniProt: Q16531)
B: 40 - 442 (UniProt: Q96SW2)
D: 96 - 378 (UniProt: P24864)
| PDB | External Database | Details |
|---|---|---|
| Trp 1141 | - | expression tag |
| Ser 1142 | - | expression tag |
| His 1143 | - | expression tag |
| Pro 1144 | - | expression tag |
| Gln 1145 | - | expression tag |
| Phe 1146 | - | expression tag |
| Glu 1147 | - | expression tag |
| Lys 1148 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 38 | - | expression tag |
| Ser 39 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 93 | - | expression tag |
| Gly 94 | - | expression tag |
| Ser 95 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 241802.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 945.5 | |
| All* | Total formula weight | 242747.4 |
