9CZT
HPK1 kinase domain T165E,S171E phosphomimetic mutant in complex with compound 6
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Mitogen-activated protein kinase kinase kinase kinase 1 | polymer | 309 | 34504.9 | 2 | UniProt (Q92918) Pfam (PF00069) | Homo sapiens (human) | Hematopoietic progenitor kinase,MAPK/ERK kinase kinase kinase 1,MEKKK 1 |
| 2 | C, D (A, B) | 4-(aminomethyl)-2-{6-[4-(propan-2-yl)-4H-1,2,4-triazol-3-yl]pyridin-2-yl}-2,3-dihydro-1H-isoindol-1-one | non-polymer | 348.4 | 2 | Chemie (A1A1E) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 479 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 307 (UniProt: Q92918)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Glu 165 | Thr 165 | engineered mutation |
| Glu 171 | Ser 171 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 69009.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 696.8 | |
| All* | Total formula weight | 69706.6 |
