9CYF
Cryo-EM structure of DA03E17 Fab in complex with influenza virus neuraminidase from A/Kansas/14/2017 (H3N2)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D, G, J (A, B, C, D) | Neuraminidase | polymer | 469 | 52145.5 | 4 | UniProt (A0A3G8EZM0) Pfam (PF00064) | Influenza A virus | |
| 2 | B, E, H, K (H, E, F, G) | DA03E17 Fab heavy chain | polymer | 231 | 24554.4 | 4 | Homo sapiens | ||
| 3 | C, F, I, L (L, I, J, K) | DA03E17 Fab light chain | polymer | 215 | 23486.0 | 4 | Homo sapiens | ||
| 4 | AA, BA, M, O, P... (a, b, M, O, P...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 12 | In PDB GlyTouCan (G42666HT) | |||
| 5 | N, R, V, Z (N, R, V, Z) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1397.2 | 4 | In PDB GlyTouCan (G80966KZ) | |||
| 6 | CA, FA, IA, LA (A, B, C, D) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 7 | DA, EA, GA, HA, JA... (A, B, C, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) |
Sequence modifications
A, B, C, D: 83 - 469 (UniProt: A0A3G8EZM0)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Asp 2 | - | expression tag |
| Ala 3 | - | expression tag |
| Met 4 | - | expression tag |
| Lys 5 | - | expression tag |
| Arg 6 | - | expression tag |
| Gly 7 | - | expression tag |
| Leu 8 | - | expression tag |
| Cys 9 | - | expression tag |
| Cys 10 | - | expression tag |
| Val 11 | - | expression tag |
| Leu 12 | - | expression tag |
| Leu 13 | - | expression tag |
| Leu 14 | - | expression tag |
| Cys 15 | - | expression tag |
| Gly 16 | - | expression tag |
| Ala 17 | - | expression tag |
| Val 18 | - | expression tag |
| Phe 19 | - | expression tag |
| Val 20 | - | expression tag |
| Ser 21 | - | expression tag |
| Pro 22 | - | expression tag |
| His 23 | - | expression tag |
| His 24 | - | expression tag |
| His 25 | - | expression tag |
| His 26 | - | expression tag |
| His 27 | - | expression tag |
| His 28 | - | expression tag |
| Gly 29 | - | expression tag |
| Ser 30 | - | expression tag |
| Ser 31 | - | expression tag |
| Ser 32 | - | expression tag |
| Ser 33 | - | expression tag |
| Asp 34 | - | expression tag |
| Tyr 35 | - | expression tag |
| Ser 36 | - | expression tag |
| Asp 37 | - | expression tag |
| Leu 38 | - | expression tag |
| Gln 39 | - | expression tag |
| Arg 40 | - | expression tag |
| Val 41 | - | expression tag |
| Lys 42 | - | expression tag |
| Gln 43 | - | expression tag |
| Glu 44 | - | expression tag |
| Leu 45 | - | expression tag |
| Leu 46 | - | expression tag |
| Glu 47 | - | expression tag |
| Glu 48 | - | expression tag |
| Val 49 | - | expression tag |
| Lys 50 | - | expression tag |
| Lys 51 | - | expression tag |
| Glu 52 | - | expression tag |
| Leu 53 | - | expression tag |
| Gln 54 | - | expression tag |
| Lys 55 | - | expression tag |
| Val 56 | - | expression tag |
| Lys 57 | - | expression tag |
| Glu 58 | - | expression tag |
| Glu 59 | - | expression tag |
| Ile 60 | - | expression tag |
| Ile 61 | - | expression tag |
| Glu 62 | - | expression tag |
| Ala 63 | - | expression tag |
| Phe 64 | - | expression tag |
| Val 65 | - | expression tag |
| Gln 66 | - | expression tag |
| Glu 67 | - | expression tag |
| Leu 68 | - | expression tag |
| Arg 69 | - | expression tag |
| Lys 70 | - | expression tag |
| Arg 71 | - | expression tag |
| Gly 72 | - | expression tag |
| Ser 73 | - | expression tag |
| Glu 74 | - | expression tag |
| Asn 75 | - | expression tag |
| Leu 76 | - | expression tag |
| Tyr 77 | - | expression tag |
| Phe 78 | - | expression tag |
| Gln 79 | - | expression tag |
| Ser 80 | - | expression tag |
| Gly 81 | - | expression tag |
| Ser 82 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 400743.9 | |
| Branched | Number of molecules | 16 |
| Total formula weight | 10681.8 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1930.0 | |
| All* | Total formula weight | 413355.7 |
