9CXH

Structure of PDE6C in complex with the rod inhibitory p gamma subunit in the presence of cGMP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	polymer	843	97724.6	2	UniProt (P51160) Pfam (PF01590) Pfam (PF00233)	Homo sapiens (human)	cGMP phosphodiesterase 6C
2	C, D (D, C)	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	polymer	99	11055.7	2	UniProt (P04972) Pfam (PF04868)	Bos taurus (cattle)	GMP-PDE gamma
3	E, I (A, B)	CYCLIC GUANOSINE MONOPHOSPHATE	non-polymer		345.2	2	Chemie (PCG)
4	F, J (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
5	G, K (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
6	H, L (A, B)	GUANOSINE-5'-MONOPHOSPHATE	non-polymer		363.2	2	Chemie (5GP)

Sequence modifications

A, B: 2 - 830 (UniProt: P51160)

PDB	External Database	Details
Gly -12	-	expression tag
Pro -11	-	expression tag
Thr -10	-	expression tag
Ser -9	-	expression tag
Gly -8	-	expression tag
Asp -7	-	expression tag
Tyr -6	-	expression tag
Lys -5	-	expression tag
Asp -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Asp -1	-	expression tag
Lys 0	-	expression tag
Gly 1	-	expression tag

D, C: 1 - 87 (UniProt: P04972)

PDB	External Database	Details
Met -11	-	expression tag
Val -10	-	expression tag
Gly -9	-	expression tag
Tyr -8	-	expression tag
Pro -7	-	expression tag
Tyr -6	-	expression tag
Asp -5	-	expression tag
Val -4	-	expression tag
Pro -3	-	expression tag
Asp -2	-	expression tag
Tyr -1	-	expression tag
Ala 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	217560.7
Non-Polymers*	Number of molecules	8
	Total formula weight	1596.3
All*	Total formula weight	219157.0

*Water molecules are not included.