9CXH
Structure of PDE6C in complex with the rod inhibitory p gamma subunit in the presence of cGMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' | polymer | 843 | 97724.6 | 2 | UniProt (P51160) Pfam (PF01590) Pfam (PF00233) | Homo sapiens (human) | cGMP phosphodiesterase 6C |
| 2 | C, D (D, C) | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma | polymer | 99 | 11055.7 | 2 | UniProt (P04972) Pfam (PF04868) | Bos taurus (cattle) | GMP-PDE gamma |
| 3 | E, I (A, B) | CYCLIC GUANOSINE MONOPHOSPHATE | non-polymer | 345.2 | 2 | Chemie (PCG) PubChem (177270406) PubChem (136759845) PubChem (135398570) PubChem (135402012) PubChem (135415582) PubChem (135530416) PubChem (135566687) PubChem (135612771) PubChem (136122637) PubChem (136183234) PubChem (136183235) PubChem (136239427) PubChem (136268916) PubChem (136454903) PubChem (136454906) PubChem (136488083) PubChem (136488088) PubChem (136499047) PubChem (136678837) PubChem (137218937) PubChem (137234705) PubChem (137279777) PubChem (138399475) PubChem (164162904) | |||
| 4 | F, J (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | G, K (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 6 | H, L (A, B) | GUANOSINE-5'-MONOPHOSPHATE | non-polymer | 363.2 | 2 | Chemie (5GP) |
Sequence modifications
A, B: 2 - 830 (UniProt: P51160)
D, C: 1 - 87 (UniProt: P04972)
| PDB | External Database | Details |
|---|---|---|
| Gly -12 | - | expression tag |
| Pro -11 | - | expression tag |
| Thr -10 | - | expression tag |
| Ser -9 | - | expression tag |
| Gly -8 | - | expression tag |
| Asp -7 | - | expression tag |
| Tyr -6 | - | expression tag |
| Lys -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Lys 0 | - | expression tag |
| Gly 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -11 | - | expression tag |
| Val -10 | - | expression tag |
| Gly -9 | - | expression tag |
| Tyr -8 | - | expression tag |
| Pro -7 | - | expression tag |
| Tyr -6 | - | expression tag |
| Asp -5 | - | expression tag |
| Val -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Tyr -1 | - | expression tag |
| Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 217560.7 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1596.3 | |
| All* | Total formula weight | 219157.0 |
