9CXG

Structure of PDE6C in complex with inhibitory cone p gamma in the presence of cGMP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	polymer	843	97724.6	2	UniProt (P51160) Pfam (PF01590) Pfam (PF00233)	Homo sapiens (human)	cGMP phosphodiesterase 6C
2	C, D (C, D)	cone P gamma	polymer	123	13195.8	2	Pfam (PF04868) UniProt (by SIFTS) (P61249)	Homo sapiens (human)
3	E, I (A, B)	CYCLIC GUANOSINE MONOPHOSPHATE	non-polymer		345.2	2	Chemie (PCG) PubChem (177270406) PubChem (136759845) PubChem (135398570) PubChem (135402012) PubChem (135415582) PubChem (135530416) PubChem (135566687) PubChem (135612771) PubChem (136122637) PubChem (136183234) PubChem (136183235) PubChem (136239427) PubChem (136268916) PubChem (136454903) PubChem (136454906) PubChem (136488083) PubChem (136488088) PubChem (136499047) PubChem (136678837) PubChem (137218937) PubChem (137234705) PubChem (137279777) PubChem (138399475) PubChem (164162904)
4	F, J (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
5	G, K (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG) PubChem (888)
6	H, L (A, B)	GUANOSINE-5'-MONOPHOSPHATE	non-polymer		363.2	2	Chemie (5GP)

Sequence modifications

A, B: 2 - 830 (UniProt: P51160)

PDB	External Database	Details
Gly -12	-	expression tag
Pro -11	-	expression tag
Thr -10	-	expression tag
Ser -9	-	expression tag
Gly -8	-	expression tag
Asp -7	-	expression tag
Tyr -6	-	expression tag
Lys -5	-	expression tag
Asp -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Asp -1	-	expression tag
Lys 0	-	expression tag
Gly 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	221840.8
Non-Polymers*	Number of molecules	8
	Total formula weight	1596.3
All*	Total formula weight	223437.1

*Water molecules are not included.