9CX9
Structure of SH3 domain of Src in complex with beta-arrestin 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (H) | Antibody fragment Fab30, heavy chain | polymer | 237 | 25512.4 | 1 | Mus musculus (house mouse) | ||
| 2 | B (L) | Antibody fragment Fab30, light chain | polymer | 215 | 23435.1 | 1 | Mus musculus (house mouse) | ||
| 3 | C (V) | Vasopressin V2 receptor | polymer | 29 | 3550.9 | 1 | UniProt (P30518) | Homo sapiens | |
| 4 | D (A) | Beta-arrestin-1 | polymer | 392 | 44049.2 | 1 | UniProt (P29066) Pfam (PF00339) Pfam (PF02752) | Rattus norvegicus (Norway rat) | Arrestin beta-1 |
| 5 | E (B) | Proto-oncogene tyrosine-protein kinase Src | polymer | 85 | 9756.6 | 1 | UniProt (P00523) Pfam (PF00018) | Gallus gallus (chicken) | Proto-oncogene c-Src,pp60c-src,p60-Src |
Sequence modifications
A: 2 - 393 (UniProt: P29066)
B: 83 - 141 (UniProt: P00523)
| PDB | External Database | Details |
|---|---|---|
| Val 59 | Cys 59 | engineered mutation |
| Cys 92 | Glu 92 | engineered mutation |
| Ser 125 | Cys 125 | engineered mutation |
| Leu 140 | Cys 140 | engineered mutation |
| Val 150 | Cys 150 | engineered mutation |
| Val 242 | Cys 242 | engineered mutation |
| Val 251 | Cys 251 | engineered mutation |
| Ser 269 | Cys 269 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met 57 | - | initiating methionine |
| Gly 58 | - | expression tag |
| Ser 59 | - | expression tag |
| Ser 60 | - | expression tag |
| His 61 | - | expression tag |
| His 62 | - | expression tag |
| His 63 | - | expression tag |
| His 64 | - | expression tag |
| His 65 | - | expression tag |
| His 66 | - | expression tag |
| Asp 67 | - | expression tag |
| Tyr 68 | - | expression tag |
| Asp 69 | - | expression tag |
| Ile 70 | - | expression tag |
| Pro 71 | - | expression tag |
| Thr 72 | - | expression tag |
| Thr 73 | - | expression tag |
| Glu 74 | - | expression tag |
| Asn 75 | - | expression tag |
| Leu 76 | - | expression tag |
| Tyr 77 | - | expression tag |
| Phe 78 | - | expression tag |
| Gln 79 | - | expression tag |
| Gly 80 | - | expression tag |
| His 81 | - | expression tag |
| Met 82 | - | expression tag |
| Cys 95 | Arg 95 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 106304.1 | |
| All* | Total formula weight | 106304.1 |
