9CX0

Crystal structure of HLA-A*03:01 E152V mutant in complex with a mutant PIK3CA peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	HLA class I histocompatibility antigen, A alpha chain	polymer	274	31598.9	1	UniProt (P04439)	Homo sapiens (human)	Human leukocyte antigen A,HLA-A
2	B (B)	Beta-2-microglobulin	polymer	100	11879.4	1	UniProt (P61769)	Homo sapiens (human)
3	C (C)	Mutant PIK3CA peptide	polymer	9	972.1	1	UniProt (P42336)	Homo sapiens
4	D, E, F, G (A, B)	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)
5	H, I, J (A, B, C)	water	water		18.0	437	Chemie (HOH)

Sequence modifications

A: 1 - 274 (UniProt: P04439)

PDB	External Database	Details
Val 152	Glu 176	engineered mutation

B: 1 - 99 (UniProt: P61769)

PDB	External Database	Details
Met 0	-	initiating methionine

C: 1 - 9 (UniProt: P42336)

PDB	External Database	Details
Leu 2	His 1047	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	44450.3
Non-Polymers*	Number of molecules	4
	Total formula weight	368.4
All*	Total formula weight	44818.7

*Water molecules are not included.