9CUI
Structure of human full-length ancestral TRPV6 channel in Calmodulin-bound state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Transient receptor potential cation channel subfamily V member 6 | polymer | 765 | 87375.4 | 4 | UniProt (Q9H1D0) Pfam (PF12796) Pfam (PF00023) Pfam (PF00520) | Homo sapiens (human) | TrpV6,CaT-like,CaT-L,Calcium transport protein 1,CaT1,Epithelial calcium channel 2,ECaC2 |
| 2 | E (E) | Calmodulin-1 | polymer | 149 | 16852.5 | 1 | UniProt (P0DP23) Pfam (PF13499) | Homo sapiens (human) | |
| 3 | AA, CB, F, MA, OA... (B, D, A, C) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 8 | Chemie (Y01) | |||
| 4 | DB, G, NA, Z (D, A, C, B) | CHOLESTEROL | non-polymer | 386.7 | 4 | Chemie (CLR) | |||
| 5 | AB, BA, BB, CA, DA... (D, B, A, C) | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 787.1 | 43 | Chemie (PCW) | |||
| 6 | JA, LB, MB, NB, OB... (B, E, A) | CALCIUM ION | non-polymer | 40.1 | 7 | Chemie (CA) |
Sequence modifications
A, B, C, D: -39 - 725 (UniProt: Q9H1D0)
| PDB | External Database | Details |
|---|---|---|
| Arg 157 | Cys 197 | variant |
| Val 378 | Met 418 | variant |
| Thr 681 | Met 721 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 366354.1 | |
| Non-Polymers* | Number of molecules | 62 |
| Total formula weight | 39567.2 | |
| All* | Total formula weight | 405921.3 |
