9CUH
Structure of human full-length ancestral TRPV6 channel in apo open state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Transient receptor potential cation channel subfamily V member 6 | polymer | 765 | 87375.4 | 4 | UniProt (Q9H1D0) Pfam (PF12796) Pfam (PF00023) Pfam (PF00520) | Homo sapiens (human) | TrpV6,CaT-like,CaT-L,Calcium transport protein 1,CaT1,Epithelial calcium channel 2,ECaC2 |
| 2 | DA, E, F, FA, GA... (C, A, B, D) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 12 | Chemie (Y01) | |||
| 3 | G, HA, V, VA (A, C, B, D) | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 787.1 | 4 | Chemie (PCW) | |||
| 4 | AA, AB, BA, CA, EA... (B, D, C, A) | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 32 | Chemie (POV) | |||
| 5 | Q (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 6 | BB, CB, DB, EB (A, B, C, D) | water | water | 18.0 | 72 | Chemie (HOH) |
Sequence modifications
A, B, C, D: -39 - 725 (UniProt: Q9H1D0)
| PDB | External Database | Details |
|---|---|---|
| Arg 157 | Cys 197 | variant |
| Val 378 | Met 418 | variant |
| Thr 681 | Met 721 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 349501.6 | |
| Non-Polymers* | Number of molecules | 49 |
| Total formula weight | 33351.7 | |
| All* | Total formula weight | 382853.3 |
