9CQ6
The ligation complex in the NHEJ pathway
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, M (A, a) | X-ray repair cross-complementing protein 6 | polymer | 612 | 70198.3 | 2 | UniProt (P12956) Pfam (PF03731) Pfam (PF02735) Pfam (PF03730) Pfam (PF02037) | Homo sapiens (human) | 5'-deoxyribose-5-phosphate lyase Ku70,5'-dRP lyase Ku70,70 kDa subunit of Ku antigen,ATP-dependent DNA helicase 2 subunit 1,ATP-dependent DNA helicase II 70 kDa subunit,CTC box-binding factor 75 kDa subunit,CTCBF,DNA repair protein XRCC6,Lupus Ku autoantigen protein p70,Ku70,Thyroid-lupus autoantigen,TLAA,X-ray repair complementing defective repair in Chinese hamster cells 6 |
| 2 | B, N (B, b) | X-ray repair cross-complementing protein 5 | polymer | 732 | 82812.4 | 2 | UniProt (P13010) Pfam (PF03731) Pfam (PF02735) Pfam (PF03730) Pfam (PF08785) | Homo sapiens (human) | |
| 3 | C, O (C, c) | Non-homologous end-joining factor 1 | polymer | 302 | 33625.5 | 2 | UniProt (Q9H9Q4) Pfam (PF21928) Pfam (PF09302) | Homo sapiens (human) | Protein cernunnos,XRCC4-like factor |
| 4 | D, E, P, Q (D, E, d, e) | DNA repair protein XRCC4 | polymer | 336 | 38337.7 | 4 | UniProt (Q13426) Pfam (PF06632) Pfam (PF21924) Pfam (PF21925) | Homo sapiens (human) | X-ray repair cross-complementing protein 4 |
| 5 | F, R (F, f) | DNA ligase 4 | polymer | 914 | 104378.3 | 2 | UniProt (P49917) Pfam (PF04675) Pfam (PF01068) Pfam (PF04679) Pfam (PF00533) Pfam (PF11411) | Homo sapiens (human) | DNA ligase IV,Polydeoxyribonucleotide synthase [ATP] 4 |
| 6 | G, H (G, H) | Protein PAXX | polymer | 218 | 23282.2 | 2 | UniProt (Q9BUH6) Pfam (PF15384) | Homo sapiens (human) | Paralog of XRCC4 and XLF,XRCC4-like small protein |
| 7 | I (I) | DNA (40-MER) | polymer | 68 | 20722.3 | 1 | Homo sapiens | ||
| 8 | J (J) | DNA (38-MER) | polymer | 68 | 20811.4 | 1 | Homo sapiens | ||
| 9 | K (K) | DNA (36-MER) | polymer | 51 | 15865.2 | 1 | Homo sapiens | ||
| 10 | L (L) | DNA (34-MER) | polymer | 51 | 15807.1 | 1 | Homo sapiens | ||
| 11 | S (L) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 1 | Chemie (AMP) |
Sequence modifications
A, a: 1 - 609 (UniProt: P12956)
C, c: 1 - 299 (UniProt: Q9H9Q4)
F, f: 1 - 911 (UniProt: P49917)
G, H: 1 - 204 (UniProt: Q9BUH6)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Pro -1 | - | expression tag |
| Val 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Pro -1 | - | expression tag |
| Val 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Pro -1 | - | expression tag |
| Val 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -13 | - | initiating methionine |
| Gly -12 | - | expression tag |
| Ser -11 | - | expression tag |
| Ser -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Gln -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Pro 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 18 |
| Total formula weight | 855150.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 347.2 | |
| All* | Total formula weight | 855497.5 |
