9CMA
Cryo-EM structure of FAN1 R507H-PCNA-DNA in final state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Fanconi-associated nuclease 1 | polymer | 646 | 73540.7 | 1 | UniProt (Q9Y2M0) Pfam (PF21315) Pfam (PF21169) Pfam (PF21170) Pfam (PF08774) | Homo sapiens (human) | FANCD2/FANCI-associated nuclease 1,hFAN1,Myotubularin-related protein 15 |
| 2 | B, C, D (B, C, D) | Proliferating cell nuclear antigen | polymer | 261 | 28795.8 | 3 | UniProt (P12004) Pfam (PF00705) Pfam (PF02747) | Homo sapiens (human) | PCNA,Cyclin |
| 3 | E (E) | DNA (46-MER) with (CAG)2 extrusion | polymer | 46 | 14231.1 | 1 | synthetic construct | ||
| 4 | F (F) | DNA (40-MER) | polymer | 40 | 12256.9 | 1 | synthetic construct |
Sequence modifications
A: 372 - 1017 (UniProt: Q9Y2M0)
| PDB | External Database | Details |
|---|---|---|
| His 507 | Arg 507 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 186416.0 | |
| All* | Total formula weight | 186416.0 |
