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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9CM7

Cryo-EM structure of Gi-coupled FFA2 in complex with TUG-1375 and AZ-1729

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(R)		Free fatty acid receptor 2polymer54461023.01UniProt (O15552)
Pfam (PF00001)		Homo sapiens (human)G-protein coupled receptor 43
2B
(A)		Guanine nucleotide-binding protein G(i) subunit alpha-1polymer35440414.01UniProt (P63096)
Pfam (PF00503)		Homo sapiens (human)Adenylate cyclase-inhibiting G alpha protein
3C
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer37640845.61UniProt (P62873)
Pfam (PF00400)		Homo sapiens (human)
4D
(G)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P59768)
Pfam (PF00631)		Homo sapiens (human)G gamma-I
5E
(N)		scFv16polymer26628634.81Mus musculus (mouse)
6F
(R)		(2R,4R)-2-(2-chlorophenyl)-3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]carbonyl-1,3-thiazolidine-4-carboxylic acidnon-polymer442.91Chemie (9UJ)
7G
(R)		N-[(3M)-3-(2-carbamimidamido-4-methyl-1,3-thiazol-5-yl)phenyl]-4-fluorobenzamidenon-polymer369.41Chemie (A1AZB)
Sequence modifications
R: 1 - 330 (UniProt: O15552)
PDBExternal DatabaseDetails
Asp -44-expression tag
Tyr -43-expression tag
Lys -42-expression tag
Asp -41-expression tag
Asp -40-expression tag
Asp -39-expression tag
Asp -38-expression tag
Gly -37-expression tag
Gln -36-expression tag
Pro -35-expression tag
Gly -34-expression tag
Asn -33-expression tag
Gly -32-expression tag
Ser -31-expression tag
Ala -30-expression tag
Phe -29-expression tag
Leu -28-expression tag
Leu -27-expression tag
Ala -26-expression tag
Pro -25-expression tag
Asn -24-expression tag
Gly -23-expression tag
Ser -22-expression tag
His -21-expression tag
Ala -20-expression tag
Pro -19-expression tag
Asp -18-expression tag
His -17-expression tag
Asn -16-expression tag
Val -15-expression tag
Thr -14-expression tag
Gln -13-expression tag
Gln -12-expression tag
Arg -11-expression tag
Asp -10-expression tag
Glu -9-expression tag
Glu -8-expression tag
Asn -7-expression tag
Leu -6-expression tag
Tyr -5-expression tag
Phe -4-expression tag
Gln -3-expression tag
Gly -2-expression tag
Val -1-expression tag
Asp 0-expression tag
Ala 331-expression tag
Ala 332-expression tag
Ala 333-expression tag
Val 334-expression tag
Phe 335-expression tag
Thr 336-expression tag
Leu 337-expression tag
Glu 338-expression tag
Asp 339-expression tag
Phe 340-expression tag
Val 341-expression tag
Gly 342-expression tag
Asp 343-expression tag
Trp 344-expression tag
Glu 345-expression tag
Gln 346-expression tag
Thr 347-expression tag
Ala 348-expression tag
Ala 349-expression tag
Tyr 350-expression tag
Asn 351-expression tag
Leu 352-expression tag
Asp 353-expression tag
Gln 354-expression tag
Val 355-expression tag
Leu 356-expression tag
Glu 357-expression tag
Gln 358-expression tag
Gly 359-expression tag
Gly 360-expression tag
Val 361-expression tag
Ser 362-expression tag
Ser 363-expression tag
Leu 364-expression tag
Leu 365-expression tag
Gln 366-expression tag
Asn 367-expression tag
Leu 368-expression tag
Ala 369-expression tag
Val 370-expression tag
Ser 371-expression tag
Val 372-expression tag
Thr 373-expression tag
Pro 374-expression tag
Ile 375-expression tag
Gln 376-expression tag
Arg 377-expression tag
Ile 378-expression tag
Val 379-expression tag
Arg 380-expression tag
Ser 381-expression tag
Gly 382-expression tag
Glu 383-expression tag
Asn 384-expression tag
Ala 385-expression tag
Leu 386-expression tag
Lys 387-expression tag
Ile 388-expression tag
Asp 389-expression tag
Ile 390-expression tag
His 391-expression tag
Val 392-expression tag
Ile 393-expression tag
Ile 394-expression tag
Pro 395-expression tag
Tyr 396-expression tag
Glu 397-expression tag
Gly 398-expression tag
Leu 399-expression tag
Ser 400-expression tag
Ala 401-expression tag
Asp 402-expression tag
Gln 403-expression tag
Met 404-expression tag
Ala 405-expression tag
Gln 406-expression tag
Ile 407-expression tag
Glu 408-expression tag
Glu 409-expression tag
Val 410-expression tag
Phe 411-expression tag
Lys 412-expression tag
Val 413-expression tag
Val 414-expression tag
Tyr 415-expression tag
Pro 416-expression tag
Val 417-expression tag
Asp 418-expression tag
Asp 419-expression tag
His 420-expression tag
His 421-expression tag
Phe 422-expression tag
Lys 423-expression tag
Val 424-expression tag
Ile 425-expression tag
Leu 426-expression tag
Pro 427-expression tag
Tyr 428-expression tag
Gly 429-expression tag
Thr 430-expression tag
Leu 431-expression tag
Val 432-expression tag
Ile 433-expression tag
Asp 434-expression tag
Gly 435-expression tag
Val 436-expression tag
Thr 437-expression tag
Pro 438-expression tag
Asn 439-expression tag
Met 440-expression tag
Leu 441-expression tag
Asn 442-expression tag
Tyr 443-expression tag
Phe 444-expression tag
Gly 445-expression tag
Arg 446-expression tag
Pro 447-expression tag
Tyr 448-expression tag
Glu 449-expression tag
Gly 450-expression tag
Ile 451-expression tag
Ala 452-expression tag
Val 453-expression tag
Phe 454-expression tag
Asp 455-expression tag
Gly 456-expression tag
Lys 457-expression tag
Lys 458-expression tag
Ile 459-expression tag
Thr 460-expression tag
Val 461-expression tag
Thr 462-expression tag
Gly 463-expression tag
Thr 464-expression tag
Leu 465-expression tag
Trp 466-expression tag
Asn 467-expression tag
Gly 468-expression tag
Asn 469-expression tag
Lys 470-expression tag
Ile 471-expression tag
Ile 472-expression tag
Asp 473-expression tag
Glu 474-expression tag
Arg 475-expression tag
Leu 476-expression tag
Ile 477-expression tag
Thr 478-expression tag
Pro 479-expression tag
Asp 480-expression tag
Gly 481-expression tag
Ser 482-expression tag
Met 483-expression tag
Leu 484-expression tag
Phe 485-expression tag
Arg 486-expression tag
Val 487-expression tag
Thr 488-expression tag
Ile 489-expression tag
Asn 490-expression tag
Ser 491-expression tag
His 492-expression tag
His 493-expression tag
His 494-expression tag
His 495-expression tag
His 496-expression tag
His 497-expression tag
His 498-expression tag
His 499-expression tag
A: 1 - 354 (UniProt: P63096)
PDBExternal DatabaseDetails
Asn 47Ser 47engineered mutation
Ala 203Gly 203engineered mutation
Ala 245Glu 245engineered mutation
Ser 326Ala 326engineered mutation
B: 2 - 340 (UniProt: P62873)
PDBExternal DatabaseDetails
Met -9-initiating methionine
His -8-expression tag
His -7-expression tag
His -6-expression tag
His -5-expression tag
His -4-expression tag
His -3-expression tag
Gly -2-expression tag
Ser -1-expression tag
Ser 0-expression tag
Gly 1-expression tag
Gly 341-expression tag
Ser 342-expression tag
Ser 343-expression tag
Gly 344-expression tag
Gly 345-expression tag
Gly 346-expression tag
Gly 347-expression tag
Ser 348-expression tag
Gly 349-expression tag
Gly 350-expression tag
Gly 351-expression tag
Gly 352-expression tag
Ser 353-expression tag
Ser 354-expression tag
Gly 355-expression tag
Val 356-expression tag
Ser 357-expression tag
Gly 358-expression tag
Trp 359-expression tag
Arg 360-expression tag
Leu 361-expression tag
Phe 362-expression tag
Lys 363-expression tag
Lys 364-expression tag
Ile 365-expression tag
Ser 366-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains5
Total formula weight178778.6
Non-Polymers*Number of molecules2
Total formula weight812.3
All*Total formula weight179590.9
*Water molecules are not included.

247536

PDB entries from 2026-01-14

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