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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9CLW

Cryo-EM structure of Gq-coupled FFA2 in complex with TUG-1375 and 4-CMTB

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Guanine nucleotide-binding protein G(q) subunit alphapolymer24628084.81Homo sapiens (human)
2B
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer37640845.61UniProt (P62873)
Pfam (PF25391)		Homo sapiens (human)
3C
(N)		scFv16polymer26628634.81Mus musculus (mouse)
4D
(R)		Free fatty acid receptor 2polymer54461023.01UniProt (O15552)
Pfam (PF00001)		Homo sapiens (human)G-protein coupled receptor 43
5E
(G)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P59768)
Pfam (PF00631)		Homo sapiens (human)G gamma-I
6F
(R)		(2R,4R)-2-(2-chlorophenyl)-3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]carbonyl-1,3-thiazolidine-4-carboxylic acidnon-polymer442.91Chemie (9UJ)
PubChem (137321147)
PubChem (138319694)
PubChem (139035877)
7G
(R)		(2~{S})-2-(4-chlorophenyl)-3-methyl-~{N}-(1,3-thiazol-2-yl)butanamidenon-polymer294.81Chemie (A1LYC)
PubChem (854189)
PubChem (854190)
PubChem (4307629)
8H
(R)		CHOLESTEROLnon-polymer386.71Chemie (CLR)
PubChem (16219173)
PubChem (16758052)
PubChem (304)
PubChem (176980071)
PubChem (40477506)
PubChem (40557614)
PubChem (42579431)
PubChem (42579432)
PubChem (18640088)
PubChem (1715243)
PubChem (1715244)
PubChem (45044259)
PubChem (23423981)
PubChem (49853509)
PubChem (50990013)
PubChem (52934537)
PubChem (56621683)
PubChem (191463)
PubChem (57915018)
PubChem (57939063)
PubChem (58428240)
PubChem (58445498)
PubChem (58663286)
PubChem (368063)
PubChem (369319)
PubChem (44654663)
PubChem (59450329)
PubChem (59628412)
PubChem (59965215)
PubChem (71234641)
PubChem (59993755)
PubChem (60001463)
PubChem (66634651)
PubChem (68055877)
PubChem (68166463)
PubChem (68315613)
PubChem (46937002)
PubChem (70795838)
PubChem (70797612)
PubChem (70954610)
PubChem (70957185)
PubChem (71463909)
PubChem (638019)
PubChem (59274407)
PubChem (1549081)
PubChem (1553803)
PubChem (68311425)
PubChem (68311398)
PubChem (143173313)
PubChem (177156123)
PubChem (89951918)
PubChem (90224410)
PubChem (5997)
PubChem (5283629)
PubChem (5284644)
PubChem (1551269)
PubChem (90070115)
PubChem (91298236)
PubChem (5315842)
PubChem (117965027)
PubChem (6432564)
PubChem (6710666)
PubChem (124146240)
PubChem (7059399)
PubChem (124897607)
PubChem (124896959)
PubChem (6419195)
PubChem (10861996)
PubChem (132837164)
PubChem (101624109)
PubChem (6994560)
PubChem (7055705)
PubChem (7055706)
PubChem (7059398)
PubChem (7059400)
PubChem (7059635)
PubChem (7103033)
PubChem (7182477)
PubChem (7182478)
PubChem (11834483)
PubChem (11888915)
PubChem (11888914)
PubChem (9909206)
PubChem (10045721)
PubChem (71168115)
PubChem (10134774)
PubChem (10293553)
PubChem (71173031)
PubChem (124225449)
PubChem (138967089)
PubChem (11003580)
PubChem (11025495)
PubChem (11058155)
PubChem (139566851)
PubChem (124429284)
PubChem (11463329)
PubChem (11868624)
PubChem (11868625)
PubChem (11869366)
PubChem (11869367)
PubChem (11869368)
PubChem (11869369)
PubChem (12120344)
PubChem (12156156)
PubChem (12303135)
PubChem (12303148)
PubChem (12303156)
PubChem (12303159)
PubChem (12303160)
PubChem (15939944)
PubChem (124909223)
PubChem (124909224)
PubChem (124909225)
PubChem (171828367)
PubChem (173516975)
PubChem (130459183)
PubChem (131992107)
PubChem (139568882)
PubChem (142983773)
PubChem (144054483)
PubChem (144209461)
PubChem (144331236)
PubChem (144808354)
PubChem (145053568)
PubChem (145157652)
PubChem (145215073)
PubChem (145230478)
PubChem (146320991)
PubChem (147857230)
PubChem (154993519)
PubChem (158603858)
PubChem (162906452)
PubChem (162906453)
PubChem (162906454)
PubChem (162906455)
PubChem (162906456)
PubChem (162906457)
PubChem (163255768)
PubChem (163389210)
PubChem (164665303)
PubChem (166553771)
PubChem (166712004)
PubChem (170116175)
PubChem (171764280)
PubChem (171817101)
PubChem (171817104)
PubChem (174285573)
9I
(R)		PALMITIC ACIDnon-polymer256.41Chemie (PLM)
Sequence modifications
B: 2 - 340 (UniProt: P62873)
PDBExternal DatabaseDetails
Met -9-initiating methionine
His -8-expression tag
His -7-expression tag
His -6-expression tag
His -5-expression tag
His -4-expression tag
His -3-expression tag
Gly -2-expression tag
Ser -1-expression tag
Ser 0-expression tag
Gly 1-expression tag
Gly 341-expression tag
Ser 342-expression tag
Ser 343-expression tag
Gly 344-expression tag
Gly 345-expression tag
Gly 346-expression tag
Gly 347-expression tag
Ser 348-expression tag
Gly 349-expression tag
Gly 350-expression tag
Gly 351-expression tag
Gly 352-expression tag
Ser 353-expression tag
Ser 354-expression tag
Gly 355-expression tag
Val 356-expression tag
Ser 357-expression tag
Gly 358-expression tag
Trp 359-expression tag
Arg 360-expression tag
Leu 361-expression tag
Phe 362-expression tag
Lys 363-expression tag
Lys 364-expression tag
Ile 365-expression tag
Ser 366-expression tag
R: 1 - 330 (UniProt: O15552)
PDBExternal DatabaseDetails
Asp -44-expression tag
Tyr -43-expression tag
Lys -42-expression tag
Asp -41-expression tag
Asp -40-expression tag
Asp -39-expression tag
Asp -38-expression tag
Gly -37-expression tag
Gln -36-expression tag
Pro -35-expression tag
Gly -34-expression tag
Asn -33-expression tag
Gly -32-expression tag
Ser -31-expression tag
Ala -30-expression tag
Phe -29-expression tag
Leu -28-expression tag
Leu -27-expression tag
Ala -26-expression tag
Pro -25-expression tag
Asn -24-expression tag
Gly -23-expression tag
Ser -22-expression tag
His -21-expression tag
Ala -20-expression tag
Pro -19-expression tag
Asp -18-expression tag
His -17-expression tag
Asn -16-expression tag
Val -15-expression tag
Thr -14-expression tag
Gln -13-expression tag
Gln -12-expression tag
Arg -11-expression tag
Asp -10-expression tag
Glu -9-expression tag
Glu -8-expression tag
Asn -7-expression tag
Leu -6-expression tag
Tyr -5-expression tag
Phe -4-expression tag
Gln -3-expression tag
Gly -2-expression tag
Val -1-expression tag
Asp 0-expression tag
Ala 331-expression tag
Ala 332-expression tag
Ala 333-expression tag
Val 334-expression tag
Phe 335-expression tag
Thr 336-expression tag
Leu 337-expression tag
Glu 338-expression tag
Asp 339-expression tag
Phe 340-expression tag
Val 341-expression tag
Gly 342-expression tag
Asp 343-expression tag
Trp 344-expression tag
Glu 345-expression tag
Gln 346-expression tag
Thr 347-expression tag
Ala 348-expression tag
Ala 349-expression tag
Tyr 350-expression tag
Asn 351-expression tag
Leu 352-expression tag
Asp 353-expression tag
Gln 354-expression tag
Val 355-expression tag
Leu 356-expression tag
Glu 357-expression tag
Gln 358-expression tag
Gly 359-expression tag
Gly 360-expression tag
Val 361-expression tag
Ser 362-expression tag
Ser 363-expression tag
Leu 364-expression tag
Leu 365-expression tag
Gln 366-expression tag
Asn 367-expression tag
Leu 368-expression tag
Ala 369-expression tag
Val 370-expression tag
Ser 371-expression tag
Val 372-expression tag
Thr 373-expression tag
Pro 374-expression tag
Ile 375-expression tag
Gln 376-expression tag
Arg 377-expression tag
Ile 378-expression tag
Val 379-expression tag
Arg 380-expression tag
Ser 381-expression tag
Gly 382-expression tag
Glu 383-expression tag
Asn 384-expression tag
Ala 385-expression tag
Leu 386-expression tag
Lys 387-expression tag
Ile 388-expression tag
Asp 389-expression tag
Ile 390-expression tag
His 391-expression tag
Val 392-expression tag
Ile 393-expression tag
Ile 394-expression tag
Pro 395-expression tag
Tyr 396-expression tag
Glu 397-expression tag
Gly 398-expression tag
Leu 399-expression tag
Ser 400-expression tag
Ala 401-expression tag
Asp 402-expression tag
Gln 403-expression tag
Met 404-expression tag
Ala 405-expression tag
Gln 406-expression tag
Ile 407-expression tag
Glu 408-expression tag
Glu 409-expression tag
Val 410-expression tag
Phe 411-expression tag
Lys 412-expression tag
Val 413-expression tag
Val 414-expression tag
Tyr 415-expression tag
Pro 416-expression tag
Val 417-expression tag
Asp 418-expression tag
Asp 419-expression tag
His 420-expression tag
His 421-expression tag
Phe 422-expression tag
Lys 423-expression tag
Val 424-expression tag
Ile 425-expression tag
Leu 426-expression tag
Pro 427-expression tag
Tyr 428-expression tag
Gly 429-expression tag
Thr 430-expression tag
Leu 431-expression tag
Val 432-expression tag
Ile 433-expression tag
Asp 434-expression tag
Gly 435-expression tag
Val 436-expression tag
Thr 437-expression tag
Pro 438-expression tag
Asn 439-expression tag
Met 440-expression tag
Leu 441-expression tag
Asn 442-expression tag
Tyr 443-expression tag
Phe 444-expression tag
Gly 445-expression tag
Arg 446-expression tag
Pro 447-expression tag
Tyr 448-expression tag
Glu 449-expression tag
Gly 450-expression tag
Ile 451-expression tag
Ala 452-expression tag
Val 453-expression tag
Phe 454-expression tag
Asp 455-expression tag
Gly 456-expression tag
Lys 457-expression tag
Lys 458-expression tag
Ile 459-expression tag
Thr 460-expression tag
Val 461-expression tag
Thr 462-expression tag
Gly 463-expression tag
Thr 464-expression tag
Leu 465-expression tag
Trp 466-expression tag
Asn 467-expression tag
Gly 468-expression tag
Asn 469-expression tag
Lys 470-expression tag
Ile 471-expression tag
Ile 472-expression tag
Asp 473-expression tag
Glu 474-expression tag
Arg 475-expression tag
Leu 476-expression tag
Ile 477-expression tag
Thr 478-expression tag
Pro 479-expression tag
Asp 480-expression tag
Gly 481-expression tag
Ser 482-expression tag
Met 483-expression tag
Leu 484-expression tag
Phe 485-expression tag
Arg 486-expression tag
Val 487-expression tag
Thr 488-expression tag
Ile 489-expression tag
Asn 490-expression tag
Ser 491-expression tag
His 492-expression tag
His 493-expression tag
His 494-expression tag
His 495-expression tag
His 496-expression tag
His 497-expression tag
His 498-expression tag
His 499-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains5
Total formula weight166449.3
Non-Polymers*Number of molecules4
Total formula weight1380.8
All*Total formula weight167830.1
*Water molecules are not included.

253389

PDB entries from 2026-05-13

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