9CKF
Crystal structure of SMYD2 secondary binding site mutant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | N-lysine methyltransferase SMYD2 | polymer | 433 | 49602.9 | 2 | UniProt (Q9NRG4) Pfam (PF00856) Pfam (PF01753) | Homo sapiens (human) | HSKM-B,Histone methyltransferase SMYD2,Lysine N-methyltransferase 3C,SET and MYND domain-containing protein 2 |
| 2 | C, H, I (A, B) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 3 | D, J (A, B) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) | |||
| 4 | E, F, G, K, L... (A, B) | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
| 5 | N, O (A, B) | water | water | 18.0 | 125 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 433 (UniProt: Q9NRG4)
| PDB | External Database | Details |
|---|---|---|
| Ala 351 | Leu 351 | engineered mutation |
| Ala 356 | Trp 356 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 99205.8 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1437.6 | |
| All* | Total formula weight | 100643.3 |
