Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9CJ7

Lineage IV Lassa virus glycoprotein (Josiah) in complex with monoclonal antibody 8.9F

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (C, A, B)	Glycoprotein G1	polymer	259	29010.4	3	UniProt (P08669) Pfam (PF00798)	Lassa virus Josiah
2	D, E, F (c, a, b)	Glycoprotein G2	polymer	420	46421.8	3	UniProt (P08669) Pfam (PF00798)	Lassa virus Josiah	GP2
3	G (H)	Fv region of 8.9F heavy chain	polymer	293	31428.8	1		Homo sapiens
4	H (L)	Fv region of 8.9F light chain	polymer	237	25244.9	1		Homo sapiens
5	I, P (D, M)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1057.0	2	In PDB GlyTouCan (G82348BZ)
6	J, N, Q, W (E, J, N, T)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	4	In PDB GlyTouCan (G15407YE)
7	AA, BA, EA, GA, IA... (X, Y, e, g, i...)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	15	In PDB GlyTouCan (G42666HT)
8	M (I)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	1	In PDB GlyTouCan (G21290RB)
9	CA, Z (Z, W)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		732.7	2	In PDB GlyTouCan (G32152BH)
10	DA, FA, HA (d, f, h)	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1073.0	3	In PDB GlyTouCan (G56014GC)
11	JA, KA, LA, MA, NA... (c, a, b)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG)

Sequence modifications

C, A, B: 1 - 259 (UniProt: P08669)

PDB	External Database	Details
Cys 207	Arg 207	conflict

c, a, b: 260 - 424 (UniProt: P08669)

PDB	External Database	Details
Pro 329	Glu 329	conflict
Cys 360	Gly 360	conflict
Gly 425	-	expression tag
Ser 426	-	expression tag
Gly 427	-	expression tag
Gly 428	-	expression tag
Ser 429	-	expression tag
Gly 430	-	expression tag
Gly 431	-	expression tag
Ser 432	-	expression tag
Gly 433	-	expression tag
Gly 434	-	expression tag
Ser 435	-	expression tag
Gly 436	-	expression tag
Gly 437	-	expression tag
Ser 438	-	expression tag
Glu 439	-	expression tag
Lys 440	-	expression tag
Ala 441	-	expression tag
Ala 442	-	expression tag
Lys 443	-	expression tag
Ala 444	-	expression tag
Glu 445	-	expression tag
Glu 446	-	expression tag
Ala 447	-	expression tag
Ala 448	-	expression tag
Arg 449	-	expression tag
Lys 450	-	expression tag
Met 451	-	expression tag
Glu 452	-	expression tag
Glu 453	-	expression tag
Leu 454	-	expression tag
Phe 455	-	expression tag
Lys 456	-	expression tag
Lys 457	-	expression tag
His 458	-	expression tag
Lys 459	-	expression tag
Ile 460	-	expression tag
Val 461	-	expression tag
Ala 462	-	expression tag
Val 463	-	expression tag
Leu 464	-	expression tag
Arg 465	-	expression tag
Ala 466	-	expression tag
Asn 467	-	expression tag
Ser 468	-	expression tag
Val 469	-	expression tag
Glu 470	-	expression tag
Glu 471	-	expression tag
Ala 472	-	expression tag
Ile 473	-	expression tag
Glu 474	-	expression tag
Lys 475	-	expression tag
Ala 476	-	expression tag
Val 477	-	expression tag
Ala 478	-	expression tag
Val 479	-	expression tag
Phe 480	-	expression tag
Ala 481	-	expression tag
Gly 482	-	expression tag
Gly 483	-	expression tag
Val 484	-	expression tag
His 485	-	expression tag
Leu 486	-	expression tag
Ile 487	-	expression tag
Glu 488	-	expression tag
Ile 489	-	expression tag
Thr 490	-	expression tag
Phe 491	-	expression tag
Thr 492	-	expression tag
Val 493	-	expression tag
Pro 494	-	expression tag
Asp 495	-	expression tag
Ala 496	-	expression tag
Asp 497	-	expression tag
Thr 498	-	expression tag
Val 499	-	expression tag
Ile 500	-	expression tag
Lys 501	-	expression tag
Ala 502	-	expression tag
Leu 503	-	expression tag
Ser 504	-	expression tag
Val 505	-	expression tag
Leu 506	-	expression tag
Lys 507	-	expression tag
Glu 508	-	expression tag
Lys 509	-	expression tag
Gly 510	-	expression tag
Ala 511	-	expression tag
Ile 512	-	expression tag
Ile 513	-	expression tag
Gly 514	-	expression tag
Ala 515	-	expression tag
Gly 516	-	expression tag
Thr 517	-	expression tag
Val 518	-	expression tag
Thr 519	-	expression tag
Ser 520	-	expression tag
Val 521	-	expression tag
Glu 522	-	expression tag
Gln 523	-	expression tag
Cys 524	-	expression tag
Arg 525	-	expression tag
Lys 526	-	expression tag
Ala 527	-	expression tag
Val 528	-	expression tag
Glu 529	-	expression tag
Ser 530	-	expression tag
Gly 531	-	expression tag
Ala 532	-	expression tag
Glu 533	-	expression tag
Phe 534	-	expression tag
Ile 535	-	expression tag
Val 536	-	expression tag
Ser 537	-	expression tag
Pro 538	-	expression tag
His 539	-	expression tag
Leu 540	-	expression tag
Asp 541	-	expression tag
Glu 542	-	expression tag
Glu 543	-	expression tag
Ile 544	-	expression tag
Ser 545	-	expression tag
Gln 546	-	expression tag
Phe 547	-	expression tag
Cys 548	-	expression tag
Lys 549	-	expression tag
Glu 550	-	expression tag
Lys 551	-	expression tag
Gly 552	-	expression tag
Val 553	-	expression tag
Phe 554	-	expression tag
Tyr 555	-	expression tag
Met 556	-	expression tag
Pro 557	-	expression tag
Gly 558	-	expression tag
Val 559	-	expression tag
Met 560	-	expression tag
Thr 561	-	expression tag
Pro 562	-	expression tag
Thr 563	-	expression tag
Glu 564	-	expression tag
Leu 565	-	expression tag
Val 566	-	expression tag
Lys 567	-	expression tag
Ala 568	-	expression tag
Met 569	-	expression tag
Lys 570	-	expression tag
Leu 571	-	expression tag
Gly 572	-	expression tag
His 573	-	expression tag
Asp 574	-	expression tag
Ile 575	-	expression tag
Leu 576	-	expression tag
Lys 577	-	expression tag
Leu 578	-	expression tag
Phe 579	-	expression tag
Pro 580	-	expression tag
Gly 581	-	expression tag
Glu 582	-	expression tag
Val 583	-	expression tag
Val 584	-	expression tag
Gly 585	-	expression tag
Pro 586	-	expression tag
Glu 587	-	expression tag
Phe 588	-	expression tag
Val 589	-	expression tag
Lys 590	-	expression tag
Ala 591	-	expression tag
Met 592	-	expression tag
Lys 593	-	expression tag
Gly 594	-	expression tag
Pro 595	-	expression tag
Phe 596	-	expression tag
Pro 597	-	expression tag
Asn 598	-	expression tag
Val 599	-	expression tag
Lys 600	-	expression tag
Phe 601	-	expression tag
Val 602	-	expression tag
Pro 603	-	expression tag
Thr 604	-	expression tag
Gly 605	-	expression tag
Gly 606	-	expression tag
Val 607	-	expression tag
Asp 608	-	expression tag
Leu 609	-	expression tag
Asp 610	-	expression tag
Asn 611	-	expression tag
Val 612	-	expression tag
Cys 613	-	expression tag
Glu 614	-	expression tag
Trp 615	-	expression tag
Phe 616	-	expression tag
Asp 617	-	expression tag
Ala 618	-	expression tag
Gly 619	-	expression tag
Val 620	-	expression tag
Leu 621	-	expression tag
Ala 622	-	expression tag
Val 623	-	expression tag
Gly 624	-	expression tag
Val 625	-	expression tag
Gly 626	-	expression tag
Asp 627	-	expression tag
Ala 628	-	expression tag
Leu 629	-	expression tag
Val 630	-	expression tag
Glu 631	-	expression tag
Gly 632	-	expression tag
Asp 633	-	expression tag
Pro 634	-	expression tag
Asp 635	-	expression tag
Glu 636	-	expression tag
Val 637	-	expression tag
Arg 638	-	expression tag
Glu 639	-	expression tag
Lys 640	-	expression tag
Ala 641	-	expression tag
Lys 642	-	expression tag
Glu 643	-	expression tag
Phe 644	-	expression tag
Val 645	-	expression tag
Glu 646	-	expression tag
Lys 647	-	expression tag
Ile 648	-	expression tag
Arg 649	-	expression tag
Gly 650	-	expression tag
Cys 651	-	expression tag
Thr 652	-	expression tag
Glu 653	-	expression tag
Gly 654	-	expression tag
Ser 655	-	expression tag
Leu 656	-	expression tag
Glu 657	-	expression tag
His 658	-	expression tag
His 659	-	expression tag
His 660	-	expression tag
His 661	-	expression tag
His 662	-	expression tag
His 663	-	expression tag
Gly 664	-	expression tag
Gly 665	-	expression tag
Leu 666	-	expression tag
Asn 667	-	expression tag
Asp 668	-	expression tag
Ile 669	-	expression tag
Phe 670	-	expression tag
Glu 671	-	expression tag
Ala 672	-	expression tag
Gln 673	-	expression tag
Lys 674	-	expression tag
Ile 675	-	expression tag
Glu 676	-	expression tag
Trp 677	-	expression tag
His 678	-	expression tag
Glu 679	-	expression tag

Sequence viewer

Contents of the asymmetric unit

Polymers	Number of chains	8
Polymers	Total formula weight	282970.1
Branched	Number of molecules	27
Branched	Total formula weight	16080.9
Non-Polymers*	Number of molecules	6
Non-Polymers*	Total formula weight	1327.2
All*	Total formula weight	300378.3

*Water molecules are not included.

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)