9CHX
cryo-EM structure of calcineurin-fused beta2 adrenergic receptor in carazolol bound inactive state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Beta-2 adrenergic receptor,Calcineurin subunit B type 1 | polymer | 449 | 51309.7 | 1 | UniProt (P07550) UniProt (P63098) Pfam (PF00001) Pfam (PF13499) | Homo sapiens (human) | |
| 2 | B (B) | Protein phosphatase 3 catalytic subunit alpha | polymer | 370 | 42627.8 | 1 | UniProt (P63328) Pfam (PF00149) | Mus musculus (house mouse) | CAM-PRP catalytic subunit,Calcineurin A alpha,Calmodulin-dependent calcineurin A subunit alpha isoform,CNA alpha,Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform |
| 3 | C (C) | Peptidyl-prolyl cis-trans isomerase FKBP1A | polymer | 108 | 11967.7 | 1 | UniProt (P62942) Pfam (PF00254) | Homo sapiens (human) | PPIase FKBP1A,12 kDa FK506-binding protein,FKBP-12,Calstabin-1,FK506-binding protein 1A,FKBP-1A,Immunophilin FKBP12,Rotamase |
| 4 | D (A) | (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol | non-polymer | 298.4 | 1 | Chemie (CAU) | |||
| 5 | E (C) | 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN | non-polymer | 804.0 | 1 | Chemie (FK5) |
Sequence modifications
A: 29 - 230 (UniProt: P07550)
A: 231 - 385 (UniProt: P63098)
A: 386 - 477 (UniProt: P07550)
| PDB | External Database | Details |
|---|---|---|
| Glu 187 | Asn 187 | conflict |
A: 386 - 477 (UniProt: P07550)
| PDB | External Database | Details |
|---|---|---|
| Asp 468 | Ser 345 | conflict |
| Asp 469 | Ser 346 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 105905.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1102.4 | |
| All* | Total formula weight | 107007.6 |
