9CHU

Cryo-EM structure of calcineurin fused beta2 adrenergic receptor in norepinephrine bound inactive state

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Beta-2 adrenergic receptor,Calcineurin subunit B type 1	polymer	431	49197.3	1	UniProt (P07550) UniProt (P63098) Pfam (PF00001) Pfam (PF13499)	Homo sapiens (human)
2	B (B)	Protein phosphatase 3 catalytic subunit alpha	polymer	370	42627.8	1	UniProt (P63328) Pfam (PF00149)	Mus musculus (house mouse)	CAM-PRP catalytic subunit,Calcineurin A alpha,Calmodulin-dependent calcineurin A subunit alpha isoform,CNA alpha,Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
3	C (C)	Peptidyl-prolyl cis-trans isomerase FKBP1A	polymer	108	11967.7	1	UniProt (P62942) Pfam (PF00254)	Homo sapiens (human)	PPIase FKBP1A,12 kDa FK506-binding protein,FKBP-12,Calstabin-1,FK506-binding protein 1A,FKBP-1A,Immunophilin FKBP12,Rotamase
4	D (A)	Noradrenaline	non-polymer		170.2	1	Chemie (E5E) PubChem (3810693) PubChem (6921839) PubChem (6921840)
5	E (C)	8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN	non-polymer		804.0	1	Chemie (FK5) PubChem (23377000) PubChem (177746942) PubChem (23308325) PubChem (23581796) PubChem (24978521) PubChem (54611630) PubChem (57206900) PubChem (44294761) PubChem (44314852) PubChem (403209) PubChem (439492) PubChem (59042420) PubChem (59111253) PubChem (59112447) PubChem (59118415) PubChem (44575549) PubChem (59746606) PubChem (46783859) PubChem (59917266) PubChem (59918741) PubChem (60086106) PubChem (46781577) PubChem (66509027) PubChem (66672804) PubChem (49874294) PubChem (71296869) PubChem (71316759) PubChem (71668407) PubChem (73265325) PubChem (57417278) PubChem (57892354) PubChem (57910335) PubChem (58584114) PubChem (59032416) PubChem (58946030) PubChem (59141120) PubChem (59049316) PubChem (59974193) PubChem (59993548) PubChem (60035606) PubChem (66709866) PubChem (67340654) PubChem (67626881) PubChem (68219140) PubChem (68712665) PubChem (69247758) PubChem (176478128) PubChem (89068341) PubChem (176856280) PubChem (177675132) PubChem (5372) PubChem (64779) PubChem (445643) PubChem (77906388) PubChem (89249909) PubChem (89545901) PubChem (89960652) PubChem (5353987) PubChem (145857191) PubChem (117646237) PubChem (6426916) PubChem (6436007) PubChem (6473866) PubChem (123552884) PubChem (5472317) PubChem (9832283) PubChem (9853905) PubChem (125039862) PubChem (9918805) PubChem (125136698) PubChem (125136697) PubChem (9963169) PubChem (129009965) PubChem (129010422) PubChem (130330191) PubChem (131676819) PubChem (6536850) PubChem (6610362) PubChem (6912836) PubChem (133562888) PubChem (133688365) PubChem (11556866) PubChem (134694629) PubChem (9940643) PubChem (12134936) PubChem (13006299) PubChem (137705868) PubChem (138106951) PubChem (138574020) PubChem (124511204) PubChem (140494820) PubChem (13819070) PubChem (140647114) PubChem (13819074) PubChem (13819069) PubChem (140893615) PubChem (13819073) PubChem (149048732) PubChem (125039860) PubChem (125039861) PubChem (125136699) PubChem (125136700) PubChem (160433486) PubChem (162711219) PubChem (163027397) PubChem (163027399) PubChem (163027400) PubChem (125182986) PubChem (126687738) PubChem (166023667) PubChem (168312998) PubChem (170277719) PubChem (171042252) PubChem (171360199) PubChem (172042935) PubChem (173882479) PubChem (129606865) PubChem (131668141) PubChem (137546410) PubChem (137546581) PubChem (138574025) PubChem (139032034) PubChem (140652196) PubChem (143265740) PubChem (144640477) PubChem (146323807) PubChem (156417380) PubChem (156528350) PubChem (160433487) PubChem (163027398) PubChem (163027401) PubChem (163027402) PubChem (167413568) PubChem (170997009) PubChem (171122179) PubChem (171137683) PubChem (171156312) PubChem (171322980) PubChem (171329370) PubChem (172634670) PubChem (175667550)

Sequence modifications

A: 29 - 230 (UniProt: P07550)

PDB	External Database	Details
Glu 187	Asn 187	conflict

A: 231 - 385 (UniProt: P63098)
A: 386 - 459 (UniProt: P07550)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	103792.8
Non-Polymers*	Number of molecules	2
	Total formula weight	974.2
All*	Total formula weight	104767.0

*Water molecules are not included.