9CHR

Cryo-EM structure of the human ether-a-go-go related K+ channel (hERG) in 300 mM K+ without symmetry

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Potassium voltage-gated channel subfamily H member 2	polymer	784	87683.4	4	UniProt (Q12809) Pfam (PF13426) Pfam (PF00520) Pfam (PF07885) Pfam (PF00027)	Homo sapiens (human)	Eag homolog,Ether-a-go-go-related gene potassium channel 1,ERG-1,Eag-related protein 1,Ether-a-go-go-related protein 1,H-ERG,hERG-1,hERG1,Voltage-gated potassium channel subunit Kv11.1

Sequence modifications

A, B, C, D: 241 - 1024 (UniProt: Q12809)

PDB	External Database	Details
-	Pro 141	deletion
-	Ala 142	deletion
-	His 143	deletion
-	Asp 144	deletion
-	Thr 145	deletion
-	Asn 146	deletion
-	His 147	deletion
-	Arg 148	deletion
-	Gly 149	deletion
-	Pro 150	deletion
-	Pro 151	deletion
-	Thr 152	deletion
-	Ser 153	deletion
-	Trp 154	deletion
-	Leu 155	deletion
-	Ala 156	deletion
-	Pro 157	deletion
-	Gly 158	deletion
-	Arg 159	deletion
-	Ala 160	deletion
-	Lys 161	deletion
-	Thr 162	deletion
-	Phe 163	deletion
-	Arg 164	deletion
-	Leu 165	deletion
-	Lys 166	deletion
-	Leu 167	deletion
-	Pro 168	deletion
-	Ala 169	deletion
-	Leu 170	deletion
-	Leu 171	deletion
-	Ala 172	deletion
-	Leu 173	deletion
-	Thr 174	deletion
-	Ala 175	deletion
-	Arg 176	deletion
-	Glu 177	deletion
-	Ser 178	deletion
-	Ser 179	deletion
-	Val 180	deletion
-	Arg 181	deletion
-	Ser 182	deletion
-	Gly 183	deletion
-	Gly 184	deletion
-	Ala 185	deletion
-	Gly 186	deletion
-	Gly 187	deletion
-	Ala 188	deletion
-	Gly 189	deletion
-	Ala 190	deletion
-	Pro 191	deletion
-	Gly 192	deletion
-	Ala 193	deletion
-	Val 194	deletion
-	Val 195	deletion
-	Val 196	deletion
-	Asp 197	deletion
-	Val 198	deletion
-	Asp 199	deletion
-	Leu 200	deletion
-	Thr 201	deletion
-	Pro 202	deletion
-	Ala 203	deletion
-	Ala 204	deletion
-	Pro 205	deletion
-	Ser 206	deletion
-	Ser 207	deletion
-	Glu 208	deletion
-	Ser 209	deletion
-	Leu 210	deletion
-	Ala 211	deletion
-	Leu 212	deletion
-	Asp 213	deletion
-	Glu 214	deletion
-	Val 215	deletion
-	Thr 216	deletion
-	Ala 217	deletion
-	Met 218	deletion
-	Asp 219	deletion
-	Asn 220	deletion
-	His 221	deletion
-	Val 222	deletion
-	Ala 223	deletion
-	Gly 224	deletion
-	Leu 225	deletion
-	Gly 226	deletion
-	Pro 227	deletion
-	Ala 228	deletion
-	Glu 229	deletion
-	Glu 230	deletion
-	Arg 231	deletion
-	Arg 232	deletion
-	Ala 233	deletion
-	Leu 234	deletion
-	Val 235	deletion
-	Gly 236	deletion
-	Pro 237	deletion
-	Gly 238	deletion
-	Ser 239	deletion
-	Pro 240	deletion
-	Pro 241	deletion
-	Arg 242	deletion
-	Ser 243	deletion
-	Ala 244	deletion
-	Pro 245	deletion
-	Gly 246	deletion
-	Gln 247	deletion
-	Leu 248	deletion
-	Pro 249	deletion
-	Ser 250	deletion
-	Pro 251	deletion
-	Arg 252	deletion
-	Ala 253	deletion
-	His 254	deletion
-	Ser 255	deletion
-	Leu 256	deletion
-	Asn 257	deletion
-	Pro 258	deletion
-	Asp 259	deletion
-	Ala 260	deletion
-	Ser 261	deletion
-	Gly 262	deletion
-	Ser 263	deletion
-	Ser 264	deletion
-	Cys 265	deletion
-	Ser 266	deletion
-	Leu 267	deletion
-	Ala 268	deletion
-	Arg 269	deletion
-	Thr 270	deletion
-	Arg 271	deletion
-	Ser 272	deletion
-	Arg 273	deletion
-	Glu 274	deletion
-	Ser 275	deletion
-	Cys 276	deletion
-	Ala 277	deletion
-	Ser 278	deletion
-	Val 279	deletion
-	Arg 280	deletion
-	Arg 281	deletion
-	Ala 282	deletion
-	Ser 283	deletion
-	Ser 284	deletion
-	Ala 285	deletion
-	Asp 286	deletion
-	Asp 287	deletion
-	Ile 288	deletion
-	Glu 289	deletion
-	Ala 290	deletion
-	Met 291	deletion
-	Arg 292	deletion
-	Ala 293	deletion
-	Gly 294	deletion
-	Val 295	deletion
-	Leu 296	deletion
-	Pro 297	deletion
-	Pro 298	deletion
-	Pro 299	deletion
-	Pro 300	deletion
-	Arg 301	deletion
-	His 302	deletion
-	Ala 303	deletion
-	Ser 304	deletion
-	Thr 305	deletion
-	Gly 306	deletion
-	Ala 307	deletion
-	Met 308	deletion
-	His 309	deletion
-	Pro 310	deletion
-	Leu 311	deletion
-	Arg 312	deletion
-	Ser 313	deletion
-	Gly 314	deletion
-	Leu 315	deletion
-	Leu 316	deletion
-	Asn 317	deletion
-	Ser 318	deletion
-	Thr 319	deletion
-	Ser 320	deletion
-	Asp 321	deletion
-	Ser 322	deletion
-	Asp 323	deletion
-	Leu 324	deletion
-	Val 325	deletion
-	Arg 326	deletion
-	Tyr 327	deletion
-	Arg 328	deletion
-	Thr 329	deletion
-	Ile 330	deletion
-	Ser 331	deletion
-	Lys 332	deletion
-	Ile 333	deletion
-	Pro 334	deletion
-	Gln 335	deletion
-	Ile 336	deletion
-	Thr 337	deletion
-	Leu 338	deletion
-	Asn 339	deletion
-	Phe 340	deletion
-	Val 341	deletion
-	Asp 342	deletion
-	Leu 343	deletion
-	Lys 344	deletion
-	Gly 345	deletion
-	Asp 346	deletion
-	Pro 347	deletion
-	Phe 348	deletion
-	Leu 349	deletion
-	Ala 350	deletion
-	Ser 351	deletion
-	Pro 352	deletion
-	Thr 353	deletion
-	Ser 354	deletion
-	Asp 355	deletion
-	Arg 356	deletion
-	Glu 357	deletion
-	Ile 358	deletion
-	Ile 359	deletion
-	Ala 360	deletion
-	Pro 361	deletion
-	Lys 362	deletion
-	Ile 363	deletion
-	Lys 364	deletion
-	Glu 365	deletion
-	Arg 366	deletion
-	Thr 367	deletion
-	His 368	deletion
-	Asn 369	deletion
-	Val 370	deletion
-	Thr 371	deletion
-	Glu 372	deletion
-	Lys 373	deletion
-	Val 374	deletion
-	Thr 375	deletion
-	Gln 376	deletion
-	Val 377	deletion
-	Leu 378	deletion
-	Ser 379	deletion
-	Leu 380	deletion
-	Ser 871	deletion
-	Pro 872	deletion
-	Gly 873	deletion
-	Ser 874	deletion
-	Thr 875	deletion
-	Glu 876	deletion
-	Leu 877	deletion
-	Glu 878	deletion
-	Gly 879	deletion
-	Gly 880	deletion
-	Phe 881	deletion
-	Ser 882	deletion
-	Arg 883	deletion
-	Gln 884	deletion
-	Arg 885	deletion
-	Lys 886	deletion
-	Arg 887	deletion
-	Lys 888	deletion
-	Leu 889	deletion
-	Ser 890	deletion
-	Phe 891	deletion
-	Arg 892	deletion
-	Arg 893	deletion
-	Arg 894	deletion
-	Thr 895	deletion
-	Asp 896	deletion
-	Lys 897	deletion
-	Asp 898	deletion
-	Thr 899	deletion
-	Glu 900	deletion
-	Gln 901	deletion
-	Pro 902	deletion
-	Gly 903	deletion
-	Glu 904	deletion
-	Val 905	deletion
-	Ser 906	deletion
-	Ala 907	deletion
-	Leu 908	deletion
-	Gly 909	deletion
-	Pro 910	deletion
-	Gly 911	deletion
-	Arg 912	deletion
-	Ala 913	deletion
-	Gly 914	deletion
-	Ala 915	deletion
-	Gly 916	deletion
-	Pro 917	deletion
-	Ser 918	deletion
-	Ser 919	deletion
-	Arg 920	deletion
-	Gly 921	deletion
-	Arg 922	deletion
-	Pro 923	deletion
-	Gly 924	deletion
-	Gly 925	deletion
-	Pro 926	deletion
-	Trp 927	deletion
-	Gly 928	deletion
-	Glu 929	deletion
-	Ser 930	deletion
-	Pro 931	deletion
-	Ser 932	deletion
-	Ser 933	deletion
-	Gly 934	deletion
-	Pro 935	deletion
-	Ser 936	deletion
-	Ser 937	deletion
-	Pro 938	deletion
-	Glu 939	deletion
-	Ser 940	deletion
-	Ser 941	deletion
-	Glu 942	deletion
-	Asp 943	deletion
-	Glu 944	deletion
-	Gly 945	deletion
-	Pro 946	deletion
-	Gly 947	deletion
-	Arg 948	deletion
-	Ser 949	deletion
-	Ser 950	deletion
-	Ser 951	deletion
-	Pro 952	deletion
-	Leu 953	deletion
-	Arg 954	deletion
-	Leu 955	deletion
-	Val 956	deletion
-	Pro 957	deletion
-	Phe 958	deletion
-	Ser 959	deletion
-	Ser 960	deletion
-	Pro 961	deletion
-	Arg 962	deletion
-	Pro 963	deletion
-	Pro 964	deletion
-	Gly 965	deletion
-	Glu 966	deletion
-	Pro 967	deletion
-	Pro 968	deletion
-	Gly 969	deletion
-	Gly 970	deletion
-	Glu 971	deletion
-	Pro 972	deletion
-	Leu 973	deletion
-	Met 974	deletion
-	Glu 975	deletion
-	Asp 976	deletion
-	Cys 977	deletion
-	Glu 978	deletion
-	Lys 979	deletion
-	Ser 980	deletion
-	Ser 981	deletion
-	Asp 982	deletion
-	Thr 983	deletion
-	Cys 984	deletion
-	Asn 985	deletion
-	Pro 986	deletion
-	Leu 987	deletion
-	Ser 988	deletion
-	Gly 989	deletion
-	Ala 990	deletion
-	Phe 991	deletion
-	Ser 992	deletion
-	Gly 993	deletion
-	Val 994	deletion
-	Ser 995	deletion
-	Asn 996	deletion
-	Ile 997	deletion
-	Phe 998	deletion
-	Ser 999	deletion
-	Phe 1000	deletion
-	Trp 1001	deletion
-	Gly 1002	deletion
-	Asp 1003	deletion
-	Ser 1004	deletion
-	Arg 1005	deletion

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	350733.4
All*	Total formula weight	350733.4

*Water molecules are not included.